ArticleNanomaterials (Basel, Switzerland)2021
In Vitro Biocompatibility Assessment of Nano-Hydroxyapatite.
Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The trial behind it
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Who cites it
43 citing papers in PubMed.
- Nanohydroxyapatite composites' toxicity and biosafety for safe clinical translation.Nanoscale advances · 2026Review
- Progress in Hydroxyapatite Nanocarriers for Targeted and Enhanced Osteoporosis Treatment: A Comprehensive Review.Molecular biotechnology · 2026Review
- New Approach Methodologies (NAMs) in Alternative Methods: A Comparative Cytotoxicity Analysis of Nanostructured Hydroxyapatite in Adipose Stem Cells Spheroids.Journal of applied toxicology : JAT · 2026Article
- Hydroxyapatite-Polysaccharide Composites Synthesized from Maize Lime-Cooking Wastewater for Bone Tissue Engineering.Journal of functional biomaterials · 2026Article
- Preparation, Biocompatibility, and In Vitro Bioactivity of High-Entropy Bio-Piezoelectric Ceramics.Materials (Basel, Switzerland) · 2026Article
- Marine Bioceramic Generation for Bone Tissue Regeneration: Sea Urchin (Echinometra mathaei) Exoskeleton-Derived Calcium Carbonate as a Precursor for Hydroxyapatite Synthesis, Incorporated into Chitosan Based-Hydrogel and 3D-Printed PCL Scaffold for Osteogenic Differentiation.Marine biotechnology (New York, N.Y.) · 2026Article
- Article
- Sustainable synthesis of biocompatible nano-hydroxyapatite from seashell (micro-mollusk) waste.RSC advances · 2026Article
- Injectable Gelatin-Farsi Gum Hydrogels Functionalized With Hydroxyapatite for Biomimetic Oral Bone Regeneration.BioMed research international · 2026Article
- Biowaste-based hydroxyapatite for bone repair: synthesis from Anadara granosa and Achatina fulica: preliminary study.Brazilian oral research · 2026Article
- 3D printed, biodegradable, and biocompatible intraperitoneal implants loaded with folic acid-targeted/pH-sensitive/doxorubicin-loaded hydroxyapatite nanoparticles for systemic treatment of metastatic breast cancer.Journal of nanobiotechnology · 2025Article
- Structural and functional properties of neodymium-doped hydroxyapatite nanoparticles for biomedical applications.Biotechnology reports (Amsterdam, Netherlands) · 2025Article
- In vitro study on the bacteriostatic effect of Amoxicillin-loaded Nano-hydroxyapatite and its capability in occluding dentinal tubules.Scientific reports · 2025Article
- New NaBMC chemistry · 2025Article
- Nanoparticles in the treatment of osteoporosis: recent advances in nanoparticles for the treatment of osteoporosis.RSC advances · 2025Review
- Osteogenesis Potential of Polymethylmethacrylate-Hydroxyapatite and Stem Cells from Human Exfoliated Deciduous Teeth as Alveolar Bone Graft: An In Silico Study.European journal of dentistry · 2025Article
- Wisdom of Crowds for Supporting the Safety Evaluation of Nanomaterials.Environmental science & technology · 2025Article
- Advances of Hydroxyapatite Nanoparticles in Dental Implant Applications.International dental journal · 2025Review
- Chitosan-Oligosaccharide-Bearing Biphasic Calcium Phosphate Bone Cement: Preparation and Angiogenic Activity In Vitro.Molecules (Basel, Switzerland) · 2025Article
- In Situ Preparation of Composite Scaffolds Based on Polyurethane and Hydroxyapatite Particles for Bone Tissue Engineering.ACS omega · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Hydroxyapatite (HA) is an important component of the bone mineral phase. It has been used in several applications, such as bone regenerative medicine, tooth implants, drug delivery and oral care cosmetics. In the present study, three different batches of a commercial nanohydroxyapatite (nHA) material were physicochemically-characterized and biologically-evaluated by means of cytotoxicity and genotoxicity using appropriate cell lines based on well-established guidelines (ISO10993-5 and OECD 487). The nHAs were characterized for their size and morphology by dynamic light scattering (DLS) and transmission electron microscopy (TEM) and were found to have a rod-like shape with an average length of approximately 20 to 40 nm. The nanoparticles were cytocompatible according to ISO 10993-5, and the in vitro micronucleus assay showed no genotoxicity to cells. Internalization by MC3T3-E1 cells was observed by TEM images, with nHA identified only in the cytoplasm and extracellular space. This result also validates the genotoxicity since nHA was not observed in the nucleus. The internalization of nHA by the cells did not seem to affect normal cell behavior, since the results showed good biocompatibility of these nHA nanoparticles. Therefore, this work is a relevant contribution for the safety assessment of this nHA material.
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Registered trials
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