ArticleViruses2021
Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort.
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Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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20citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Do COVID-19 CT features vary between patients from within and outside mainland China? Findings from a meta-analysis.Frontiers in public health · 2022Pooled it
- A 22 month prospective assessment of neutralizing and IgG antibody levels against SARS-CoV-2 variants following homologous and heterologous BNT162b2 boosting.Scientific reports · 2025Article
- Persistence and decay of neutralizing antibody responses elicited by SARS-CoV-2 infection and hybrid immunity in a Canadian cohort.Microbiology spectrum · 2025Article
- Prevalence and clinical implications of anti-drug antibody formation and serum drug levels among patients with IBD receiving anti-TNF therapy: A cross-sectional study.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2025Article
- Humoral immunoprofiling identifies novel biomarkers and an immune suppressive autoantibody phenotype at the site of disease in pancreatic ductal adenocarcinoma.Frontiers in oncology · 2024Article
- SARS-CoV-2 S-RBD IgG & Neutralizing antibodies among different categories of health care workers post third dose BNT162b2 mRNA COVID-19 vaccine.Human vaccines & immunotherapeutics · 2023Article
- SARS-CoV-2 antibody response duration and neutralization following natural infection.Journal of clinical virology plus · 2023Article
- Persistence of SARS-CoV-2 IgG Antibody Response among South African Adults: A Prospective Cohort Study.Vaccines · 2023Article
- Patients with ACPA-positive and ACPA-negative rheumatoid arthritis show different serological autoantibody repertoires and autoantibody associations with disease activity.Scientific reports · 2023Article
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- SARS-CoV-2 Serosurveys: How Antigen, Isotype and Threshold Choices Affect the Outcome.The Journal of infectious diseases · 2023Article
- Massively-multiplexed epitope mapping techniques for viral antigen discovery.Frontiers in immunology · 2023Review
- Dynamics of T-cell Responses Following COVID-19 mRNA Vaccination and Breakthrough Infection in Older Adults.Pathogens & immunity · 2023Article
- A review of mass spectrometry-based analyses to understand COVID-19 convalescent plasma mechanisms of action.Proteomics · 2022Review
- Immunogenicity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Ad26.CoV2.S Vaccination in People Living With Human Immunodeficiency Virus (HIV).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- SARS-CoV-2 herd immunity of the Kyrgyz population in 2021.Medical microbiology and immunology · 2022Article
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- Ethnicity-Specific Features of COVID-19 Among Arabs, Africans, South Asians, East Asians, and Caucasians in the United Arab Emirates.Frontiers in cellular and infection microbiology · 2021Article
- Performance of the EUROIMMUN Anti-SARS-CoV-2 ELISA Assay for detection of IgA and IgG antibodies in South Africa.PloS one · 2021Article
Corrections and comments
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Authors and funding
27 authors at 6 institutions in 3 countries.
Muneerah SmithDepartment of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.
Houari B AbdesselemNeurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University, Qatar. Foundation, Doha P.O. Box 34110, Qatar.
Michelle MullinsDepartment of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.ORCID 0000-0002-8719-0390
Ti-Myen TanSengenics Corporation, Level M, Plaza Zurich, Damansara Heights, Kuala Lumpur 50490, Malaysia.
Andrew J M NelDepartment of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.
Maryam A Y Al-NesfHamad General Hospital, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar.
Ilham BensmailNeurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University, Qatar. Foundation, Doha P.O. Box 34110, Qatar.
Nour K MajbourNeurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University, Qatar. Foundation, Doha P.O. Box 34110, Qatar.
Nishant N VaikathNeurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University, Qatar. Foundation, Doha P.O. Box 34110, Qatar.
Adviti NaikNeurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University, Qatar. Foundation, Doha P.O. Box 34110, Qatar.
Khalid OuararhniNeurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University, Qatar. Foundation, Doha P.O. Box 34110, Qatar.
Vidya Mohamed-AliAnti-Doping Laboratory Qatar, Sports City Road, Aspire Zone, Doha P.O. Box 27775, Qatar.
Mohammed Al-MaadheedAnti-Doping Laboratory Qatar, Sports City Road, Aspire Zone, Doha P.O. Box 27775, Qatar.ORCID 0000-0001-5517-0128
Darien T SchellDepartment of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.
Seanantha S Baros-SteylDepartment of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.ORCID 0000-0003-4787-4082
Nur D AnuarSengenics Corporation, Level M, Plaza Zurich, Damansara Heights, Kuala Lumpur 50490, Malaysia.ORCID 0000-0002-8210-6559
Nur H IsmailSengenics Corporation, Level M, Plaza Zurich, Damansara Heights, Kuala Lumpur 50490, Malaysia.
Priscilla E MorrisSengenics Corporation, Level M, Plaza Zurich, Damansara Heights, Kuala Lumpur 50490, Malaysia.
Raja N R MamatSengenics Corporation, Level M, Plaza Zurich, Damansara Heights, Kuala Lumpur 50490, Malaysia.
Nurul S M RosliSengenics Corporation, Level M, Plaza Zurich, Damansara Heights, Kuala Lumpur 50490, Malaysia.
Arif AnwarSengenics Corporation, Level M, Plaza Zurich, Damansara Heights, Kuala Lumpur 50490, Malaysia.
Kavithambigai EllanVirology Lab, Level 2, Block C7, Infectious Disease Research Centre, Institute for Medical Research, Setia Alam, Selangor 40170, Malaysia.
Rozainanee M ZainVirology Lab, Level 2, Block C7, Infectious Disease Research Centre, Institute for Medical Research, Setia Alam, Selangor 40170, Malaysia.
Wendy A BurgersDivision of Medical Virology, Department of Pathology, University of Cape Town, Cape Town 7925, South Africa.
Elizabeth S MayneDepartment of Immunology, National Health Laboratory Service (NHLS) and University of the Witwatersrand, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg 2196, South Africa.
Omar M A El-AgnafNeurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University, Qatar. Foundation, Doha P.O. Box 34110, Qatar.ORCID 0000-0002-6850-8084
Jonathan M BlackburnDepartment of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.ORCID 0000-0001-8988-9595
Hamad bin Khalifa University · QAUniversity of Cape Town · ZAAnti-Doping Laboratory · QAInstitute for Medical Research · MYHamad General Hospital · QANational Health Laboratory Service · ZA
Funding
Establishment of an H3Africa Biorepository at Contract Laboratory ServicesUH3HG007438 · NHGRI · WITS HEALTH CONSORTIUM (PTY), LTD · PI MAYNE, ELIZABETH · 2014 to 2018
$4.5MHuman Heredity and Health in Africa Consortium BiorepositoryU24HG007438 · NHGRI · WITS HEALTH CONSORTIUM (PTY), LTD · PI MAYNE, ELIZABETH · 2019 to 2022
$1.3MHamad Medical Corporation MRC-05-003National Research Foundation South Africa 64760NHGRI NIH HHS U24 HG007438NHGRI NIH HHS UH3 HG007438Qatar Biomedical Research Institute 0000
Abstract
The COVID-19 pandemic has affected all individuals across the globe in some way. Despite large numbers of reported seroprevalence studies, there remains a limited understanding of how the magnitude and epitope utilization of the humoral immune response to SARS-CoV-2 viral anti-gens varies within populations following natural infection. Here, we designed a quantitative, multi-epitope protein microarray comprising various nucleocapsid protein structural motifs, including two structural domains and three intrinsically disordered regions. Quantitative data from the microarray provided complete differentiation between cases and pre-pandemic controls (100% sensitivity and specificity) in a case-control cohort (
Indexed as
AdolescentAdultAntibodies, ViralAntigens, ViralCase-Control StudiesCohort StudiesCOVID-19COVID-19 Serological TestingEpitopesEthnicityFemaleHumansImmunity, HumoralImmunoglobulin GMaleMiddle AgedAntibodies, ViralAntigens, ViralEpitopesImmunoglobulin GNucleocapsid Proteinsepitope coveragehumoral responseimmunoassayprotein microarrayquantitative antibody bindingSARS-CoV-2 antibodiesSARS-CoV-2 nucleocapsid protein
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LicenceCC BY
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.