Evidence map›Paper›PMID 33925003›Full record

ArticleBiomolecules2021

The Role of Alcohol, LPS Toxicity, and ALDH2 in Dental Bony Defects.

Hsiao-Cheng Tsai, Che-Hong Chen, Daria Mochly-Rosen, Yi-Chen Ethan Li, Min-Huey Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Hsiao-Cheng TsaiGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei 100, Taiwan.
Che-Hong ChenDepartment of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, CA 94305, USA.
Daria Mochly-RosenDepartment of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, CA 94305, USA.
Yi-Chen Ethan LiDepartment of Chemical Engineering, Feng Chia University, Taichung 407, Taiwan.
Min-Huey ChenGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei 100, Taiwan.
Stanford University · USFeng Chia University · TWNational Taiwan University · TWNational Taiwan University Hospital · TW

Funding

MECHANISMS OF ETHANOL-INDUCED CARDIAC PROTECTIONR01AA011147 · NIAAA · STANFORD UNIVERSITY · PI DARIA MOCHLY-ROSEN · 1996 to 2026
$8.2M
Mechanisms of Ethanol-Induced Cardiac ProtectionR37AA011147 · NIAAA · STANFORD UNIVERSITY · PI MOCHLY-ROSEN, DARIA · 2009 to 2018
$5.3M
Ministry of Science and Technology, Taiwan MOST 107-2314-B-002-093-MY3NIAAA NIH HHS R01 AA011147NIAAA NIH HHS R37 AA011147
6 · The paper itself

Abstract

It is estimated that 560 million people carry an East Asian-specific ALDH2*2 dominant-negative mutation which leads to enzyme inactivation. This common ALDH2 polymorphism has a significant association with osteoporosis. We hypothesized that the ALDH2*2 mutation in conjunction with periodontal

Indexed as

Alcohol DrinkingAldehyde Dehydrogenase, MitochondrialAnimalsBone RegenerationCalcification, PhysiologicCell LineCell ProliferationHumansLipopolysaccharidesMaleMiceMice, Inbred C57BLOsteoblastsPeriodontitisPorphyromonas gingivalisX-Ray MicrotomographyAldehyde Dehydrogenase, MitochondrialLipopolysaccharidesalcoholALDH2dental bone lossLPSmineralizationosteoblastperiodontal disease

Identifiers

PMID33925003
PMCPMC8145216
OpenAlexW3159679141

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.