ArticleNanomaterials (Basel, Switzerland)2021
Numerical Modelling of the Optical Properties of Plasmonic and Latex Nanoparticles to Improve the Detection Limit of Immuno-Turbidimetric Assays.
Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Finite element modeling of plasmonic resonances in photothermal gold nanoparticles embedded in cells.Nanoscale advances · 2024Article
- Progress in Procalcitonin Detection Based on Immunoassay.Research (Washington, D.C.) · 2024Review
- Lactoferrin Inhibition of the Complex Formation between ACE2 Receptor and SARS CoV-2 Recognition Binding Domain.International journal of molecular sciences · 2022Article
- Consistency Analysis of 3 Detection Systems for Measuring Serum C-Reactive Protein.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
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2 authors.
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Abstract
Turbidimetric assays with latex nanoparticles are widely applied for the detection of biological analytes, because of their rapidity, low cost, reproducibility, and automatization. However, the detection limit can be lowered only at the price of a reduced dynamic range, due to the rapid saturation of the light scattering signal at high analyte concentration. Here, we use numerical calculations to investigate the possibility of increasing the performance of immuno-turbidimetric assays without compromising the measurement dynamic range, by combining plasmonic (gold, silver) and latex nanoparticles. Our modelling results show that plasmonic nanoparticles are compatible with a large signal change even when small aggregates are formed, i.e., at low analyte concentration. The working principle relies on the remarkable modification of the surface plasmon band when noble metal nanoparticles form oligomers, and also when latex particles are included in the aggregate. At high analyte concentration, when larger aggregates form, the latex particles can provide the required linear response of standard immuno-turbidimetric assays. Thus, the combination of the two components can be a successful strategy to improve the detection limit and the dynamic range, while maintaining all the advantages of the homogeneous immuno-turbidimetric assays.
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