ReviewInternational journal of molecular sciences2021
Regulatory Role of Sex Hormones in Cardiovascular Calcification.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 50 citations in OpenAlex.
- Long-term remodeling of compliance matched tissue engineered vascular grafts is sex specific.Acta biomaterialia · 2026Article
- Review
- Valvular Heart Diseases in Swedish Males and Females: A National Cohort Study.JACC. Advances · 2026Article
- New insights into sexual dimorphism in cardiometabolic health.Hormones (Athens, Greece) · 2026Review
- The association between time-weighted cumulative life's essential 8 and aortic valve calcification.Frontiers in cardiovascular medicine · 2026Article
- Predictive value of thyroid autoantibodies for coronary heart disease severity in individuals with normal thyroid function based on machine learning and SHAP interpretation.Frontiers in immunology · 2026Article
- Bone and Cardiometabolic Connection: Crosstalk between Osteoporosis and Atherosclerosis.Cell biochemistry and biophysics · 2025Review
- PDZ domain containing protein 1 aggravates mouse vascular smooth muscle cells calcification via PDZ1 domain mediated β-catenin stabilization and nuclear translocation.Communications biology · 2025Article
- Hormonal and Sex-Specific Regulation of Key Players in Fibro-Calcific Aortic Valve Disease.International journal of molecular sciences · 2025Article
- Article
- Antisense Oligonucleotide Targeting Sortilin Reduces Vascular Calcification in Mice in a Sex-Dependent Manner.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Aortic Stenosis: Time for a Sex-Based Approach?Journal of clinical medicine · 2025Review
- The hidden interplay between sex and adverse outcomes in incident dialysis patients: the role of aortic calcification.Clinical kidney journal · 2025Article
- Insulin resistance assessed by estimated glucose disposal rate and the risk of abdominal aortic calcification: findings from a nationwide cohort study.Frontiers in endocrinology · 2025Article
- Association of Serum Total Bilirubin Level With Abdominal Aortic Calcification: A Population-Based Cross-Sectional Study.Mediators of inflammation · 2025Article
- Calciprotein particles induce arterial stiffening ex vivo and impair vascular cell function.Communications biology · 2024Article
- Age-specific sex differences in intravascular ultrasound based coronary atherosclerotic plaque characteristics.American heart journal plus : cardiology research and practice · 2024Article
- Long sleep duration is associated with abdominal aortic calcification among male adults with chronic kidney disease: NHANES 2013-2014.Scientific reports · 2024Article
- Longitudinal associations between urinary biomarkers of phthalates and replacements with novel in vivo measures of placental health.Human reproduction (Oxford, England) · 2024Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Sex differences in cardiovascular disease (CVD), including aortic stenosis, atherosclerosis and cardiovascular calcification, are well documented. High levels of testosterone, the primary male sex hormone, are associated with increased risk of cardiovascular calcification, whilst estrogen, the primary female sex hormone, is considered cardioprotective. Current understanding of sexual dimorphism in cardiovascular calcification is still very limited. This review assesses the evidence that the actions of sex hormones influence the development of cardiovascular calcification. We address the current question of whether sex hormones could play a role in the sexual dimorphism seen in cardiovascular calcification, by discussing potential mechanisms of actions of sex hormones and evidence in pre-clinical research. More advanced investigations and understanding of sex hormones in calcification could provide a better translational outcome for those suffering with cardiovascular calcification.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.