Evidence map›Paper›PMID 33924801›Full record

Observational studyCurrent oncology (Toronto, Ont.)2021

Trajectory of End-of-Life Pain and Other Physical Symptoms among Cancer Patients Receiving Home Care.

Hsien Seow, Dawn M Guthrie, Tara Stevens, Lisa C Barbera, Fred Burge, Kimberlyn McGrail, Kelvin K W Chan, Stuart J Peacock, Rinku Sutradhar

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Current oncology (Toronto, Ont.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  11. Trend analysis of quality indicators in palliative home care among terminally ill cancer and non-cancer patients in Taiwan: a 6-year observational study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Observational
  12. Article
  13. Review
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  15. Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 1 country.

Hsien SeowDepartment of Oncology, McMaster University, Hamilton, ON L8S 4L8, Canada.ORCID 0000-0001-6701-1714
Dawn M GuthrieDepartment of Health Sciences, Wilfrid Laurier University, Waterloo, ON N2L 3C5, Canada.ORCID 0000-0003-3241-6580
Tara StevensDepartment of Health Sciences, Wilfrid Laurier University, Waterloo, ON N2L 3C5, Canada.
Lisa C BarberaDepartment of Oncology, University of Calgary, Calgary, AB T2N 1N4, Canada.
Fred BurgeDepartment of Family Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Kimberlyn McGrailSchool of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0002-9349-1915
Kelvin K W ChanDepartment of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.
Stuart J PeacockCanadian Centre for Applied Research in Cancer Control, Vancouver, BC V5Z 1L3, Canada.
Rinku SutradharInstitute for Clinical Evaluative Sciences, Toronto, ON M4N 3M5, Canada.
Wilfrid Laurier University · CABC Cancer Agency · CADalhousie University · CAInstitute for Clinical Evaluative Sciences · CASunnybrook Health Science Centre · CAUniversity of British Columbia · CAUniversity of Calgary · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe the trajectory of physical symptoms among cancer decedents who were receiving home care in the six months before death. PATIENTS AND

methodsAn observational cohort study of cancer decedents in Ontario, Canada, who received home care services between 2007 and 2014. To be included, decedents had to use at least one home care service in the last six months of life. Outcomes were the presence of pain and several other physical symptoms at each week before death.

resultsOur cohort included 27,295 cancer decedents (30,368 assessments). Forty-seven percent were female and 56% were age 75 years or older. The prevalence of all physical symptoms increased as one approached death, particularly in the last month of life. In the last weeks of life, 69% of patients reported having moderate-severe pain; however, only 20% reported that the pain was not controlled. Loss of appetite (63%), shortness of breath (59%), high health instability (50%), and self-reported poor health (44%) were also highly prevalent in the last week of life. Multivariate regression showed that caregiver distress, high health instability, social decline, uncontrolled pain, and signs of depression all worsened the odds of having a physical symptom in the last 3 months of life.

conclusionIn this large home care cancer cohort, trajectories of physical symptoms worsened close to death. While presence of moderate-severe pain was common, it was also reported as mostly controlled. Covariates, such as caregiver distress and social decline, were associated with having more physical symptoms at end of life.

Indexed as

Home Care ServicesNeoplasmsAgedDeathFemaleHumansOntarioPainPalliative CareRetrospective Studiescancerend of lifehome carepalliativesymptoms

Identifiers

PMID33924801
PMCPMC8161760
OpenAlexW3158247825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.