Evidence map›Paper›PMID 33924752›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Study of Cytotoxic and Photodynamic Activities of Dyads Composed of a Zinc Phthalocyanine Appended to an Organotin.

Isabelle Toubia, Christophe Nguyen, Stéphane Diring, Marine Pays, Elodie Mattana, Philippe Arnoux, Céline Frochot, Magali Gary-Bobo, Marwan Kobeissi, Fabrice Odobel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Isabelle ToubiaCEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, CNRS, UMR CNRS 6230, Université de Nantes, 2, rue de la Houssinière-BP 92208, CEDEX 3, 44322 Nantes, France.
Christophe NguyenIBMM, Université de Montpellier, CNRS, ENSCM, 34093 Montpellier, France.ORCID 0000-0003-4539-1677
Stéphane DiringCEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, CNRS, UMR CNRS 6230, Université de Nantes, 2, rue de la Houssinière-BP 92208, CEDEX 3, 44322 Nantes, France.ORCID 0000-0001-7108-3569
Marine PaysIBMM, Université de Montpellier, CNRS, ENSCM, 34093 Montpellier, France.
Elodie MattanaIBMM, Université de Montpellier, CNRS, ENSCM, 34093 Montpellier, France.
Philippe ArnouxLRGP, Laboratoire Réactions et Génie des Procédés, UMR 7274 CNRS-Université de Lorraine, 1 rue Grandville, 54000 Nancy, France.ORCID 0000-0002-6834-9597
Céline FrochotLRGP, Laboratoire Réactions et Génie des Procédés, UMR 7274 CNRS-Université de Lorraine, 1 rue Grandville, 54000 Nancy, France.ORCID 0000-0002-7659-3864
Magali Gary-BoboIBMM, Université de Montpellier, CNRS, ENSCM, 34093 Montpellier, France.ORCID 0000-0001-9641-212X
Marwan KobeissiLaboratoire Rammal Rammal, Equipe de Synthèse Organique Appliquée SOA, Faculté des Sciences 5, Université Libanaise, Nabatieh, Lebanon.ORCID 0000-0002-1872-9890
Fabrice OdobelCEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, CNRS, UMR CNRS 6230, Université de Nantes, 2, rue de la Houssinière-BP 92208, CEDEX 3, 44322 Nantes, France.ORCID 0000-0001-7289-4160
Centre National de la Recherche Scientifique · FRÉcole Nationale Supérieure de Chimie de Montpellier · FRLebanese University · LB

Funding

Campus France Eiffel grantCNRS-L IT fellowshipConseil régionnal Pays de la Loire LumomatLebanese University IT fellowship
6 · The paper itself

Abstract

The combination of photodynamic therapy and chemotherapy is a promising strategy to enhance cancer therapeutic efficacy and reduce drug resistance. In this study two zinc(II) phthalocyanine-tin(IV) conjugates linked by a triethylene glycol chain were synthesized and characterized. In these complexes, the zinc(II) phthalocyanine was used as a potential photosensitizer for PDT and the tin complex was selected as cytostatic moiety. The two dyads composed of zinc(II) phthalocyanine and tin complexes exhibited high cytotoxicity, in absence of light stimulation, against MCF-7 human breast cancer cells with low LC

Indexed as

chemotherapyphotodynamic therapytin complexzinc (II) phthalocyanine

Identifiers

PMID33924752
PMCPMC8145453
OpenAlexW3158115210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.