Evidence map›Paper›PMID 33924734›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Feasibility of Developing Radiotracers for MDM2: Synthesis and Preliminary Evaluation of an

Satish K Chitneni, Zhengyuan Zhou, Brian E Watts, Michael R Zalutsky

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Satish K ChitneniDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0003-1183-2286
Zhengyuan ZhouDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Brian E WattsDuke Human Vaccine Institute, Duke University, Durham, NC 27708, USA.ORCID 0000-0003-1731-2441
Michael R ZalutskyDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Duke Medical Center · USDuke University · US

Funding

Flourine-18 labeled MDM2 antagonists for PET imagingR21CA241823 · NCI · DUKE UNIVERSITY · PI CHITNENI, SATISH K. · 2020 to 2021
$414k
NCI NIH HHS R21 CA241823NIH HHS CA241823
6 · The paper itself

Abstract

Murine double minute 2 (MDM2), a negative regulator of the p53 tumor suppressor protein, is overexpressed in several human cancers. Herein we investigate the feasibility of developing

Indexed as

fluorine-18HepG2imagingMCF-7MDM2MDM2 inhibitorPETradiotracerSP-141

Identifiers

PMID33924734
PMCPMC8070256
OpenAlexW3156467351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.