Evidence map›Paper›PMID 33924681›Full record

ArticleBiomolecules2021

The Neuropeptide Nocistatin Is Not a Direct Agonist of Acid-Sensing Ion Channel 1a (ASIC1a).

Sven Kuspiel, Dominik Wiemuth, Stefan Gründer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Opioid system and related ligands: from the past to future perspectives.Journal of anesthesia, analgesia and critical care · 2024
    Review
  2. A conserved peptide-binding pocket in HyNaC/ASIC ion channels.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sven KuspielInstitute of Physiology, RWTH Aachen University, 52056 Aachen, Germany.
Dominik WiemuthInstitute of Physiology, RWTH Aachen University, 52056 Aachen, Germany.
Stefan GründerInstitute of Physiology, RWTH Aachen University, 52056 Aachen, Germany.ORCID 0000-0002-7635-9883
RWTH Aachen University · DE

Funding

Deutsche Forschungsgemeinschaft GR1771/8-1
6 · The paper itself

Abstract

Acid-sensing ion channels (ASICs) are ionotropic receptors that are directly activated by protons. Although protons have been shown to act as a neurotransmitter and to activate ASICs during synaptic transmission, it remains a possibility that other ligands directly activate ASICs as well. Neuropeptides are attractive candidates for alternative agonists of ASICs, because related ionotropic receptors are directly activated by neuropeptides and because diverse neuropeptides modulate ASICs. Recently, it has been reported that the neuropeptide nocistatin directly activates ASICs, including ASIC1a. Here we show that nocistatin does not directly activate ASIC1a expressed in

Indexed as

Acid Sensing Ion ChannelsAnimalsCHO CellsCricetinaeCricetulusIon Channel GatingOpioid PeptidesProtein BindingRatsXenopus laevisAcid Sensing Ion ChannelsAsic1 protein, ratnocistatinOpioid Peptidesacid-sensing ion channelneuropeptidenocistatin

Identifiers

PMID33924681
PMCPMC8070164
OpenAlexW3156391247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.