Evidence map›Paper›PMID 33924468›Full record

ArticleCells2021

Brain

Paola Castrogiovanni, Cristina Sanfilippo, Rosa Imbesi, Grazia Maugeri, Debora Lo Furno, Daniele Tibullo, Alessandro Castorina, Giuseppe Musumeci, Michelino Di Rosa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Paola CastrogiovanniDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-5873-2456
Cristina SanfilippoIRCCS Centro Neurolesi Bonino Pulejo, Strada Statale 113, C.da Casazza, 98124 Messina, Italy.
Rosa ImbesiDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-4228-4163
Grazia MaugeriDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-0173-4885
Debora Lo FurnoDepartment of Biomedical and Biotechnological Sciences, Physiology Section, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-1971-8990
Daniele TibulloDepartment of Drug Science, Biochemistry Section, University of Catania, 95125 Catania, Italy.ORCID 0000-0002-4416-8556
Alessandro CastorinaLaboratory of Cellular and Molecular Neuroscience (LCMN), School of Life Sciences, Faculty of Science, University of Technology Sydney, Broadway, NSW 2007, Australia.ORCID 0000-0001-7037-759X
Giuseppe MusumeciDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-8260-8890
Michelino Di RosaDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-1837-9325
University of Catania · ITCentro Neurolesi Bonino Pulejo · ITUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease is a progressive, devastating, and irreversible brain disorder that, day by day, destroys memory skills and social behavior. Despite this, the number of known genes suitable for discriminating between AD patients is insufficient. Among the genes potentially involved in the development of AD, there are the chitinase-like proteins (CLPs) CHI3L1, CHI3L2, and CHID1. The genes of the first two have been extensively investigated while, on the contrary, little information is available on CHID1. In this manuscript, we conducted transcriptome meta-analysis on an extensive sample of brains of healthy control subjects (n = 1849) (NDHC) and brains of AD patients (n = 1170) in order to demonstrate CHID1 involvement. Our analysis revealed an inverse correlation between the brain

Indexed as

AgedAged, 80 and overAlzheimer DiseaseBrainBrain MappingCalbindin 1Calcium-Binding ProteinsCarrier ProteinsCase-Control StudiesComputational BiologyFemaleGene Expression ProfilingGene Expression RegulationHumansMaleMicrofilament ProteinsAIF1 protein, humanCALB1 protein, humanCalbindin 1Calcium-Binding ProteinsCarrier ProteinsCHID1 protein, humanMicrofilament ProteinsNeurograninNRGN protein, humanAlzheimer’s diseasebioinformaticsCHID1chitinases

Identifiers

PMID33924468
PMCPMC8069241
OpenAlexW3156902040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.