Evidence map›Paper›PMID 33924458›Full record

ArticleBiomolecules2021

Cardioprotective Effect of Glycyrrhizin on Myocardial Remodeling in Diabetic Rats.

Vikram Thakur, Narah Alcoreza, Monica Delgado, Binata Joddar, Munmun Chattopadhyay

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Glycyrrhizic Acid Alleviates Atherosclerosis inInternational journal of molecular sciences · 2026
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  17. Bee venom ameliorates cardiac dysfunction in diabetic hyperlipidemic rats.Experimental biology and medicine (Maywood, N.J.) · 2021
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Vikram ThakurCenter of Emphasis in Diabetes and Metabolism, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA.
Narah AlcorezaGraduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA.
Monica DelgadoInspired Materials & Stem-Cell Based Tissue Engineering Laboratory (IMSTEL), Department of Metallurgical, Materials and Biomedical Engineering, The University of Texas at El Paso, El Paso, TX 79968, USA.
Binata JoddarInspired Materials & Stem-Cell Based Tissue Engineering Laboratory (IMSTEL), Department of Metallurgical, Materials and Biomedical Engineering, The University of Texas at El Paso, El Paso, TX 79968, USA.
Munmun ChattopadhyayCenter of Emphasis in Diabetes and Metabolism, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA.ORCID 0000-0003-4870-718X
Texas Tech University · USThe University of Texas at El Paso · US

Funding

Development and validation of a novel bioprinted, human-diabetic cardiac organoid modelSC1HL154511 · NHLBI · UNIVERSITY OF TEXAS EL PASO · PI HAN, KYUNG-AN · 2020 to 2023
$1.2M
NHLBI NIH HHS SC1 HL154511Texas Tech University Start up
6 · The paper itself

Abstract

Myocardial fibrosis is one of the major complications of long-term diabetes. Hyperglycemia induced cardiomyocyte atrophy is a frequent pathophysiological indicator of diabetic heart. The objective of this study was to investigate the cardioprotective effect of glycyrrhizin (GLC) on myocardial damage in diabetic rats and assess the anti-inflammatory and anti-fibrotic effect of GLC. Our study demonstrates that hyperglycemia can elevate cardiac atrophy in diabetic animals. Type 2 diabetic fatty and the lean control rats were evaluated for cardiac damage and inflammation at 8-12 weeks after the development of diabetes. Western blot and immunohistochemical studies revealed that gap junction protein connexin-43 (CX43), cardiac injury marker troponin I, cardiac muscle specific voltage gated sodium channel Na

Indexed as

AnimalsAnti-Inflammatory AgentsCardiotonic AgentsCell LineConnexin 43Diabetic CardiomyopathiesFibrosisGlycyrrhizic AcidHumansMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelNF-E2-Related Factor 2p38 Mitogen-Activated Protein KinasesRatsRats, ZuckerReceptor for Advanced Glycation End ProductsAnti-Inflammatory AgentsCardiotonic AgentsConnexin 43Cxcr4 protein, ratGlycyrrhizic AcidNAV1.5 Voltage-Gated Sodium ChannelNF-E2-Related Factor 2p38 Mitogen-Activated Protein KinasesReceptor for Advanced Glycation End ProductsReceptors, CXCR4Scn5a protein, ratTransforming Growth Factor betaTroponin Icardiac atrophyCXCR4diabeticglycyrrhizininflammation

Identifiers

PMID33924458
PMCPMC8069839
OpenAlexW3155306049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.