Evidence map›Paper›PMID 33924438›Full record

ArticleInternational journal of molecular sciences2021

Ultra-High Performance Liquid Chromatography-High Resolution Mass Spectrometry and High-Sensitivity Gas Chromatography-Mass Spectrometry Screening of Classic Drugs and New Psychoactive Substances and Metabolites in Urine of Consumers.

Emilia Marchei, Maria Alias Ferri, Marta Torrens, Magí Farré, Roberta Pacifici, Simona Pichini, Manuela Pellegrini

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Molecular Insights on New Psychoactive Substances (NPSs).International journal of molecular sciences · 2022
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Emilia MarcheiNational Centre on Addiction and Doping, Istituto Superiore di Sanità, V.Le Regina Elena 299, 00161 Rome, Italy.ORCID 0000-0002-7158-6032
Maria Alias FerriDrug Addiction Program, Institut de Neuropsiquiatria i Addicions, Institut Hopsital del Mar d'Investigacions Mèdiques (INAD-IMIM), Parc de Salut Mar, 08003 Barcelona, Spain.
Marta TorrensDrug Addiction Program, Institut de Neuropsiquiatria i Addicions, Institut Hopsital del Mar d'Investigacions Mèdiques (INAD-IMIM), Parc de Salut Mar, 08003 Barcelona, Spain.ORCID 0000-0001-6222-4761
Magí FarréDepartment of Psychiatry and Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallés, Spain.ORCID 0000-0001-8338-7543
Roberta PacificiNational Centre on Addiction and Doping, Istituto Superiore di Sanità, V.Le Regina Elena 299, 00161 Rome, Italy.
Simona PichiniNational Centre on Addiction and Doping, Istituto Superiore di Sanità, V.Le Regina Elena 299, 00161 Rome, Italy.
Manuela PellegriniNational Centre on Addiction and Doping, Istituto Superiore di Sanità, V.Le Regina Elena 299, 00161 Rome, Italy.ORCID 0000-0003-3348-5297
Istituto Superiore di Sanità · ITUniversitat Autònoma de Barcelona · ES

Funding

European Commission under the Call JUST-2017 806996-JUSTSO
6 · The paper itself

Abstract

The use of the new psychoactive substances is continuously growing and the implementation of accurate and sensible analysis in biological matrices of users is relevant and fundamental for clinical and forensic purposes. Two different analytical technologies, high-sensitivity gas chromatography-mass spectrometry (GC-MS) and ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) were used for a screening analysis of classic drugs and new psychoactive substances and their metabolites in urine of formed heroin addicts under methadone maintenance therapy. Sample preparation involved a liquid-liquid extraction. The UHPLC-HRMS method included Accucore™ phenyl Hexyl (100 × 2.1 mm, 2.6 μm, Thermo, USA) column with a gradient mobile phase consisting of mobile phase A (ammonium formate 2 mM in water, 0.1% formic acid) and mobile phase B (ammonium formate 2 mM in methanol/acetonitrile 50:50 (

Indexed as

Gas Chromatography-Mass SpectrometryAnalgesics, OpioidChromatography, High Pressure LiquidHumansMethadonePsychotropic DrugsSubstance-Related DisordersAnalgesics, OpioidMethadonePsychotropic Drugsclassic drugs of abusegas chromatography-mass spectrometryhigh-resolution mass spectrometryliquid chromatographynew psychoactive substances (NPS)novel synthetic opioids (NSO)urine

Identifiers

PMID33924438
PMCPMC8069063
OpenAlexW3152565976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.