Evidence map›Paper›PMID 33924401›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Natural and Enantiopure Alkylglycerols as Antibiofilms Against Clinical Bacterial Isolates and Quorum Sensing Inhibitors of

Klauss E Chaverra Daza, Edelberto Silva Gómez, Bárbara D Moreno Murillo, Humberto Mayorga Wandurraga

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. 1-Marine drugs · 2022
    Article
  7. Quorum Sensing Inhibiting Activity of Cefoperazone and Its Metallic Derivatives onFrontiers in cellular and infection microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Klauss E Chaverra DazaPosgrado Interfacultades de Microbiología, Facultad de Ciencias, Universidad Nacional de Colombia, Av. Carrera 30 # 45-03, Edif. 224, Bogotá 11011, Colombia.
Edelberto Silva GómezGrupo de Productos Naturales Vegetales Bioactivos y Química Ecológica, Laboratorio de Asesorías e Investigaciones en Microbiología, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Av. Carrera 30 # 45-03, Edif. 450, Bogotá 11011, Colombia.ORCID 0000-0002-9162-143X
Bárbara D Moreno MurilloGrupo de Productos Naturales Vegetales Bioactivos y Química Ecológica, Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Av. Carrera 30 # 45-03, Edif. 451, Bogotá 11011, Colombia.
Humberto Mayorga WandurragaGrupo de Productos Naturales Vegetales Bioactivos y Química Ecológica, Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Av. Carrera 30 # 45-03, Edif. 451, Bogotá 11011, Colombia.ORCID 0000-0002-2273-3112

Funding

Vicerrectoria de Investigación, Universidad Nacional de Colombia Project number 46978.
6 · The paper itself

Abstract

Resistance mechanisms occur in almost all clinical bacterial isolates and represent one of the most worrisome health problems worldwide. Bacteria can form biofilms and communicate through quorum sensing (QS), which allow them to develop resistance against conventional antibiotics. Thus, new therapeutic candidates are sought. We focus on alkylglycerols (AKGs) because of their recently discovered quorum sensing inhibition (QSI) ability and antibiofilm potential. Fifteen natural enantiopure AKGs were tested to determine their effect on the biofilm formation of other clinical bacterial isolates, two reference strains and their QSI was determined using

Indexed as

1-O-alkyl-sn-glycerolsantibiofilm activityantimicrobial resistanceether lipidsnatural alkylglycerolsquorum sensing inhibition

Identifiers

PMID33924401
PMCPMC8070063

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.