Evidence map›Paper›PMID 33924393›Full record

ArticleMolecules (Basel, Switzerland)2021

Synthesis and Antiviral Activity of Camphene Derivatives against Different Types of Viruses.

Anastasiya S Sokolova, Valentina P Putilova, Olga I Yarovaya, Anastasiya V Zybkina, Ekaterina D Mordvinova, Anna V Zaykovskaya, Dmitriy N Shcherbakov, Iana R Orshanskaya, Ekaterina O Sinegubova, Iana L Esaulkova and 7 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. A Comparison between BulgarianMolecules (Basel, Switzerland) · 2024
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  7. Article
  8. Combinatorial chemistry & high throughput screening · 2023
    Review
  9. Article
  10. Synthesis of conjugates of (aRussian chemical bulletin = Izvestiia Akademii nauk. Seriia khimicheskaia · 2023
    Article
  11. Review
  12. Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Anastasiya S SokolovaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Lavrent'ev av., 9, 630090 Novosibirsk, Russia.
Valentina P PutilovaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Lavrent'ev av., 9, 630090 Novosibirsk, Russia.
Olga I YarovayaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Lavrent'ev av., 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-2333-4893
Anastasiya V ZybkinaState Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Novosibirsk, Russia.
Ekaterina D MordvinovaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Lavrent'ev av., 9, 630090 Novosibirsk, Russia.
Anna V ZaykovskayaState Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Novosibirsk, Russia.
Dmitriy N ShcherbakovState Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Novosibirsk, Russia.ORCID 0000-0001-8023-4453
Iana R OrshanskayaPasteur Institute of Epidemiology and Microbiology, 14 Mira str., 197101 St. Petersburg, Russia.
Ekaterina O SinegubovaPasteur Institute of Epidemiology and Microbiology, 14 Mira str., 197101 St. Petersburg, Russia.ORCID 0000-0001-9490-2280
Iana L EsaulkovaPasteur Institute of Epidemiology and Microbiology, 14 Mira str., 197101 St. Petersburg, Russia.
Sophia S BorisevichLaboratory of Chemical Physics, Ufa Institute of Chemistry Ufa Federal Research Center, 71 Pr. Oktyabrya, 450078 Ufa, Russia.
Nikolay I BormotovState Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Novosibirsk, Russia.
Larisa N ShishkinaState Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Novosibirsk, Russia.
Vladimir V ZarubaevPasteur Institute of Epidemiology and Microbiology, 14 Mira str., 197101 St. Petersburg, Russia.ORCID 0000-0002-5224-3771
Oleg V PyankovState Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Novosibirsk, Russia.
Rinat A MaksyutovState Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Novosibirsk, Russia.
Nariman F SalakhutdinovN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Lavrent'ev av., 9, 630090 Novosibirsk, Russia.
State Research Center of Virology and Biotechnology VECTOR · RUNovosibirsk Institute of Organic Chemistry · RUSaint Petersburg Pasteur Institute · RUUfa Institute of Chemistry · RU

Funding

Russian Science Foundation 19-73-00125
6 · The paper itself

Abstract

To date, the 'one bug-one drug' approach to antiviral drug development cannot effectively respond to the constant threat posed by an increasing diversity of viruses causing outbreaks of viral infections that turn out to be pathogenic for humans. Evidently, there is an urgent need for new strategies to develop efficient antiviral agents with broad-spectrum activities. In this paper, we identified camphene derivatives that showed broad antiviral activities in vitro against a panel of enveloped pathogenic viruses, including influenza virus A/PR/8/34 (H1N1), Ebola virus (EBOV), and the Hantaan virus. The lead-compound

Indexed as

Antiviral AgentsBicyclic MonoterpenesEbolavirusMagnetic Resonance SpectroscopyModels, MolecularOrthomyxoviridaeProtein Structure, SecondaryPyrrolidinesAntiviral AgentsBicyclic MonoterpenescamphenepyrrolidinePyrrolidinesantiviral agentcamphenmolecular dockingpseudotype virusessurface protein

Identifiers

PMID33924393
PMCPMC8070564
OpenAlexW3156337027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.