SynthesisInternational journal of environmental research and public health2021
Lung Damage Caused by Heated Tobacco Products and Electronic Nicotine Delivery Systems: A Systematic Review.
Synthesis in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Health impacts of electronic nicotine delivery systems: an umbrella review of systematic reviews.BMJ open · 2025Pooled it
- Respiratory health effects of e-cigarette substitution for tobacco cigarettes: a systematic review.Harm reduction journal · 2023Pooled it
- Chemical Profiles and Toxicity of Electronic Cigarettes: An Umbrella Review and Methodological Considerations.International journal of environmental research and public health · 2023Pooled it
- Health Effects of Electronic Cigarettes: An Umbrella Review and Methodological Considerations.International journal of environmental research and public health · 2022Pooled it
- Sharing Antivaping Social Media Messages.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025Trial
- Article
- Blood Pressure and Salivary Cotinine Levels in Young Adults Using Heated Tobacco Products: A Case-Control Study in Poland.Healthcare (Basel, Switzerland) · 2026Article
- Strengthening Tobacco Product Regulation: Addressing Challenges and Strategies for Articles 9 and 10 Implementation.Health care analysis : HCA : journal of health philosophy and policy · 2025Article
- Comparison of Elicit AI and Traditional Literature Searching in Evidence Syntheses Using Four Case Studies.Cochrane evidence synthesis and methods · 2025Article
- Smoking Cessation Strategies for Different Types of Cigarette Users Using a Digital Peer-Supported App and Nicotine Aids: Prospective Study.Journal of medical Internet research · 2025Article
- Article
- Comparative analysis of the toxic effects on the mouse lung of 4 weeks exposure to the heated tobacco product Ploom TECH+ and 3R4F reference cigarettes.Journal of toxicologic pathology · 2025Article
- Article
- A Bibliometric Study of Interleukin Cytokines in the Treatment of Intervertebral Disc Degeneration.Drug design, development and therapy · 2025Article
- Nicotine is an Immunosuppressant: Implications for Women's Health and Disease.Journal of neuroimmunology · 2024Review
- Tobacco and COPD: presenting the World Health Organization (WHO) Tobacco Knowledge Summary.Respiratory research · 2024Review
- The role of puff volume in vaping emissions, inhalation risks, and metabolic perturbations: a pilot study.Scientific reports · 2024Article
- Association between heated tobacco product use and airway obstruction: a single-centre observational study, Japan.BMJ open respiratory research · 2024Observational
- Safety, efficacy and health impact of electronic nicotine delivery systems (ENDS): an umbrella review protocol.BMJ open · 2024Article
- Impact of exposures to Heated Tobacco Products in the media and through social connections on product perceptions and use.Tobacco prevention & cessation · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tobacco industry promotes electronic nicotine delivery systems (ENDS) and heated tobacco products (HTP) as a safer alternative to conventional cigarettes with misleading marketing sustained by studies with conflict of interest. As a result, these devices sell without regulations and warnings about their adverse effects on health, with a growing user base targeting young people. This systematic review aimed to describe the adverse effects on the respiratory system in consumers of these devices. We conducted a systematic review and bibliometric analysis of 79 studies without conflict of interest evaluating ENDS and HTP effects in the respiratory system in experimental models, retrieved from the PubMed database. We found that the damage produced by using these devices is involved in pathways related to pulmonary diseases, involving mechanisms previously reported in conventional cigarettes as well as new mechanisms particular to these devices, which challenges that the tobacco industry's claims. The present study provides significant evidence to suggest that these devices are an emerging public health problem and that they should be regulated or avoided.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.