Evidence map›Paper›PMID 33924373›Full record

ArticleInternational journal of molecular sciences2021

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation.

Manami Deshimaru, Mariko Kinoshita-Kawada, Kaori Kubota, Takuya Watanabe, Yasuyoshi Tanaka, Saito Hirano, Fumiyoshi Ishidate, Masaki Hiramoto, Mitsuru Ishikawa, Yoshinari Uehara and 7 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 36 citations in OpenAlex.

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  12. Common genetic risk for Parkinson's disease and dysfunction of the endo-lysosomal system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
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  15. Article
  16. Review
  17. Perry Disease: Expanding the Genetic Basis.Movement disorders clinical practice · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Manami DeshimaruDepartment of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
Mariko Kinoshita-KawadaDepartment of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
Kaori KubotaDepartment of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.
Takuya WatanabeDepartment of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.ORCID 0000-0003-0131-8646
Yasuyoshi TanakaResearch Institute for the Molecular Pathomechanisms of Epilepsy, Fukuoka University, Fukuoka 814-0180, Japan.
Saito HiranoNational Hospital Organization, Kokura Medical Center, Kitakyushu, Fukuoka 802-8533, Japan.
Fumiyoshi IshidateBioanalysis Unit, iCeMS Analysis Center, Institute for Integrated Cell-Material Sciences, Kyoto University Institute for Advanced Study, Kyoto University, Kyoto 606-8501, Japan.
Masaki HiramotoDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA.
Mitsuru IshikawaDepartment of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Yoshinari UeharaFaculty of Sports and Health Science, Fukuoka University, Fukuoka 814-0180, Japan.ORCID 0000-0001-6075-7329
Hideyuki OkanoDepartment of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.ORCID 0000-0001-7482-5935
Shinichi HiroseResearch Institute for the Molecular Pathomechanisms of Epilepsy, Fukuoka University, Fukuoka 814-0180, Japan.
Shinsuke FujiokaDepartment of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
Katsunori IwasakiDepartment of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.
Junichi Yuasa-KawadaDepartment of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.ORCID 0000-0002-1382-3159
Takayasu MishimaDepartment of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
Yoshio TsuboiDepartment of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.ORCID 0000-0002-6758-0981
Fukuoka University · JPKeio University · JPKyoto University · JPNational Hospital Organization · JPScripps Research Institute · US

Funding

JSPS KAKENHI 20K22663, 18K15471
6 · The paper itself

Abstract

A common pathological hallmark of several neurodegenerative diseases, including amyotrophic lateral sclerosis, is cytoplasmic mislocalization and aggregation of nuclear RNA-binding protein TDP-43. Perry disease, which displays inherited atypical parkinsonism, is a type of TDP-43 proteinopathy. The causative gene

Indexed as

Protein AggregatesAmino Acid SequenceAnimalsCell Line, TumorChlorocebus aethiopsCOS CellsDNA-Binding ProteinsDynactin ComplexHumansInduced Pluripotent Stem CellsModels, BiologicalMutant ProteinsNeuronsNuclear Localization SignalsPoint MutationProtein BindingDCTN1 protein, humanDNA-Binding ProteinsDynactin ComplexMutant ProteinsNuclear Localization SignalsProtein AggregatesTARDBP protein, humanaggregatesALSDCTN1dynactinnucleocytoplasmic transportPerry diseasePerry syndromeproteinopathyTDP-43

Identifiers

PMID33924373
PMCPMC8070438
OpenAlexW3154130453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.