Evidence map›Paper›PMID 33924314›Full record

ArticlePharmaceutics2021

Pharmacokinetic Disposition of Amiodarone When Given with an Intralipid Rescue Strategy.

Sean N Avedissian, Michelle Pham, Medha D Joshi, Marc H Scheetz, Ashkan Salamatipour, Jeffin M Panickar, Khrystyna Hlukhenka, Cristina Miglis, Athanasios Chalkias, Theodoros Xanthos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Sean N AvedissianAntiviral Pharmacology Laboratory, Center for Drug Discovery, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA.ORCID 0000-0002-0935-6455
Michelle PhamAntiviral Pharmacology Laboratory, Center for Drug Discovery, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA.
Medha D JoshiDepartment of Pharmaceutical Sciences, College of Pharmacy-Glendale, Midwestern University, Glendale, AZ 85308, USA.ORCID 0000-0002-0280-0349
Marc H ScheetzDepartment of Pharmacy Practice, Midwestern University College of Pharmacy, Downers Grove, IL 60515, USA.ORCID 0000-0002-1091-6130
Ashkan SalamatipourDepartment of Pharmaceutical Sciences, Midwestern University College of Pharmacy, Downers Grove, IL 60615, USA.
Jeffin M PanickarDepartment of Pharmaceutical Sciences, Midwestern University College of Pharmacy, Downers Grove, IL 60615, USA.
Khrystyna HlukhenkaDepartment of Pharmaceutical Sciences, Midwestern University College of Pharmacy, Downers Grove, IL 60615, USA.
Cristina MiglisDepartment of Pharmaceutical Sciences, Midwestern University College of Pharmacy, Downers Grove, IL 60615, USA.
Athanasios ChalkiasDepartment of Anesthesiology, Faculty of Medicine, University of Thessaly, 41500 Larisa, Greece.
Theodoros XanthosDepartment of Physiology and Pathophysiology, School of Medicine, European University Cyprus, Nicosia 1516, Cyprus.
Midwestern University · USUniversity of Nebraska Medical Center · USEuropean University Cyprus · CYUniversity of Thessaly · GR

Funding

Discretionary research grants of Dr. Joshi, Xanthos, and Scheetz. Discretionary research grants
6 · The paper itself

Abstract

While the antiarrhythmic drug amiodarone is commonly used in clinical practice, it has a narrow therapeutic index that can lead to acute overdose. One proposed method to deal with this toxicity is lipid emulsion therapy, which may potentially quench the free amiodarone in blood and prevent its further distribution to target organs and tissues. In this study, we utilize an established swine model to examine the effects of Intralipid™ (IL) administration for acute amiodarone toxicity. A total of 14 pigs received an overdose of intravenous amiodarone. After twenty minutes, half of the pigs (

Indexed as

amiodaroneHPLCIntralipidpharmacokineticpig

Identifiers

PMID33924314
PMCPMC8069539
OpenAlexW3155634549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.