Evidence map›Paper›PMID 33924306›Full record

ArticlePharmaceutics2021

Divergent Regulation of OCT and MATE Drug Transporters by Cadmium Exposure.

Hong Yang, Shiwei Zhou, Dong Guo, Obinna N Obianom, Qing Li, Yan Shu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Hong YangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.
Shiwei ZhouDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.ORCID 0000-0001-5411-4378
Dong GuoDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, Baltimore, MD 21201, USA.
Obinna N ObianomDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, Baltimore, MD 21201, USA.
Qing LiDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.ORCID 0000-0002-1787-4180
Yan ShuDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.
University of Maryland, Baltimore · USCentral South University · CN

Funding

National Science and Technology Major Project 2019ZX09201-002-006U.S. Food and Drug Administration 2U01FD005946
6 · The paper itself

Abstract

Coordinated transcellular transport by the uptake via organic cation transporters (OCTs) in concert with the efflux via multidrug and toxin extrusion proteins (MATEs) is an essential system for hepatic and renal drug disposition. Despite their clinical importance, the regulation of OCTs and MATEs remains poorly characterized. It has been reported that cadmium (Cd

Indexed as

cadmiumcandesartankidneylivermultidrug and toxin extrusion proteins (MATEs)organic cation transporters (OCTs)

Identifiers

PMID33924306
PMCPMC8069296
OpenAlexW3155770618

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.