Evidence map›Paper›PMID 33924296›Full record

ArticleVaccines2021

Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018-19 Season.

Rakefet Pando, Shahar Stern, Ital Nemet, Aharona Glatman-Freedman, Hanna Sefty, Neta S Zuckerman, Yaron Drori, Nehemya Friedman, John W McCauley, Lital Keinan-Boker and 3 more

Abstract read
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rakefet PandoThe Israel Center for Disease Control, Israel Ministry of Health, Tel-Hashomer, Ramat-Gan 52621, Israel.
Shahar SternChaim Sheba Medical Center, Central Virology Laboratory, Ministry of Health, Ramat-Gan 52621, Israel.ORCID 0000-0002-3865-7820
Ital NemetChaim Sheba Medical Center, Central Virology Laboratory, Ministry of Health, Ramat-Gan 52621, Israel.
Aharona Glatman-FreedmanThe Israel Center for Disease Control, Israel Ministry of Health, Tel-Hashomer, Ramat-Gan 52621, Israel.
Hanna SeftyThe Israel Center for Disease Control, Israel Ministry of Health, Tel-Hashomer, Ramat-Gan 52621, Israel.
Neta S ZuckermanThe Israel Center for Disease Control, Israel Ministry of Health, Tel-Hashomer, Ramat-Gan 52621, Israel.
Yaron DroriChaim Sheba Medical Center, Central Virology Laboratory, Ministry of Health, Ramat-Gan 52621, Israel.
Nehemya FriedmanChaim Sheba Medical Center, Central Virology Laboratory, Ministry of Health, Ramat-Gan 52621, Israel.
John W McCauleyWorldwide Influenza Center, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0002-4744-6347
Lital Keinan-BokerThe Israel Center for Disease Control, Israel Ministry of Health, Tel-Hashomer, Ramat-Gan 52621, Israel.
Ella MendelsonChaim Sheba Medical Center, Central Virology Laboratory, Ministry of Health, Ramat-Gan 52621, Israel.
Rodney S DanielsWorldwide Influenza Center, The Francis Crick Institute, London NW1 1AT, UK.
Michal MandelboimChaim Sheba Medical Center, Central Virology Laboratory, Ministry of Health, Ramat-Gan 52621, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While vaccination is considered the most effective means to prevent influenza infection, its seasonal effectiveness varies, depending on the circulating influenza strains. Here, we characterized the circulation of influenza strains in October-2018 and March-2019 around the world. For this, we used nasopharyngeal samples collected from outpatient and hospitalized patients in Israel and data reported in ECDC, CDC, and WHO databases. Influenza A(H3N2) was dominant in Israel, while in Europe, Asia, and USA, A(H1N1)pdm09 virus circulated first, and then the A(H3N2) virus also appeared. Phylogenetic analysis indicated that A(H3N2) viruses circulating in Israel belonged to clade-3C.3a, while in Europe, Asia, and USA, A(H3N2) viruses belonged to subclade-3C.2a1, but were later replaced by clade-3C.3a viruses in USA. The vaccine A(H3N2) components of that year, A/Singapore/INFIMH-16-0019/2016-(H3N2)-like-viruses, belonged to clade-3C.2a1. The circulation of different influenza subtypes and clades of A(H3N2) viruses in a single season highlights the need for universal influenza vaccines.

Indexed as

circulationcladeinfluenza Avaccine

Identifiers

PMID33924296
PMCPMC8069444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.