Evidence map›Paper›PMID 33924222›Full record

ReviewInternational journal of molecular sciences2021

Molecular and Genetic Factors Involved in Olfactory and Gustatory Deficits and Associations with Microbiota in Parkinson's Disease.

Melania Melis, Antje Haehner, Mariano Mastinu, Thomas Hummel, Iole Tomassini Barbarossa

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Neurobiology of Parkinson's Disease.International journal of molecular sciences · 2023
    Article
  10. Article
  11. Article
  12. Olfactory Bulb DToxins · 2022
    Article
  13. Assessment of Taste Function.Handbook of experimental pharmacology · 2022
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Melania MelisDepartment of Biomedical Sciences, University of Cagliari, Monserrato, 09042 Cagliari, Italy.ORCID 0000-0003-3410-3158
Antje HaehnerSmell and Taste Clinic, Department of Otorhinolaryngology, Technical University of Dresden, 01307 Dresden, Germany.
Mariano MastinuDepartment of Biomedical Sciences, University of Cagliari, Monserrato, 09042 Cagliari, Italy.
Thomas HummelSmell and Taste Clinic, Department of Otorhinolaryngology, Technical University of Dresden, 01307 Dresden, Germany.
Iole Tomassini BarbarossaDepartment of Biomedical Sciences, University of Cagliari, Monserrato, 09042 Cagliari, Italy.ORCID 0000-0002-2849-4052

Funding

Grant from University of Cagliari 5 x mille, 2017
6 · The paper itself

Abstract

Deficits in olfaction and taste are among the most frequent non-motor manifestations in Parkinson's disease (PD) that start very early and frequently precede the PD motor symptoms. The limited data available suggest that the basis of the olfactory and gustatory dysfunction related to PD are likely multifactorial and may include the same determinants responsible for other non-motor symptoms of PD. This review describes the most relevant molecular and genetic factors involved in the PD-related smell and taste impairments, and their associations with the microbiota, which also may represent risk factors associated with the disease.

Indexed as

Disease SusceptibilityMicrobiotaOlfactory PerceptionTaste PerceptionAgnosiaBiomarkersGenetic Predisposition to DiseaseGenetic VariationHumansModels, BiologicalParkinson DiseaseBiomarkersParkinson’s diseasesmelltaste

Identifiers

PMID33924222
PMCPMC8074606

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.