Evidence map›Paper›PMID 33924204›Full record

ArticleBiomedicines2021

Circulating microRNAs Related to Bone Metabolism in HIV-Associated Bone Loss.

Maria P Yavropoulou, Artemis Kolynou, Polyzois Makras, Maria Pikilidou, Sideris Nanoudis, Lemonia Skoura, Olga Tsachouridou, Georgios Ntritsos, Alexandros Tzallas, Dimitrios G Tsalikakis and 3 more

Abstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maria P YavropoulouEndocrinology Unit, The First Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0002-6501-3692
Artemis KolynouDepartment of Microbiology, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Polyzois MakrasLaboratory of Medical Research, 251 Hellenic Air Force & VA General Hospital, 11525 Athens, Greece.ORCID 0000-0002-3231-3357
Maria PikilidouFirst Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Sideris NanoudisFirst Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.ORCID 0000-0002-0199-8672
Lemonia SkouraDepartment of Microbiology, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Olga TsachouridouFirst Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Georgios NtritsosDepartment of Informatics & Telecommunications, School of Informatics & Telecommunications, University of Ioannina, 47100 Arta, Greece.
Alexandros TzallasDepartment of Informatics & Telecommunications, School of Informatics & Telecommunications, University of Ioannina, 47100 Arta, Greece.ORCID 0000-0001-9043-1290
Dimitrios G TsalikakisDepartment of Engineering Informatics and Telecommunications, University of Western Macedonia, 50100 Kozani, Greece.
Olga TsaveLaboratory of Medical Research, 251 Hellenic Air Force & VA General Hospital, 11525 Athens, Greece.
Simeon MetallidisFirst Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Dimitrios ChatzidimitriouNational AIDS Reference Centre of Northern Greece, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathophysiology of human immunodeficiency virus (HIV)-associated bone loss is complex and to date largely unknown. In this study, we investigated serum expression of microRNAS (miRNAs) linked to bone metabolism in HIV-associated bone loss. This was a case-control study. Thirty male individuals with HIV infection (HIV+) and osteoporosis/osteopenia (HIV+/OP+) (cases) and 30 age-matched male HIV+ individuals with normal bone mass (HIV+/OP-) (controls) were included in the analysis. Thirty male individuals matched for age without HIV infection (HIV-), were also included as second controls. The selected panel of miRNAs was as follows: hsa-miRNA-21-5p; hsa-miRNA-23a-3p; hsa-miRNA-24-2-5p; hsa-miRNA-26a-5p; hsa-miRNA-29a-3p; hsa-miRNA-124-3p; hsa-miRNA-33a-5p; and hsa-miRNA-133a-3p. Within the cohort of HIV+ individuals, relative serum expression of miRNA-21-5p and miRNA-23a-3p was significantly lower (

Indexed as

antiretroviral therapybone metabolismcirculating miRNAsHIV infectionosteoblastsosteoclastsosteoporosis

Identifiers

PMID33924204
PMCPMC8074601

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.