Evidence map›Paper›PMID 33924172›Full record

ArticleBiomedicines2021

Mineralocorticoid Receptor Antagonists Eplerenone and Spironolactone Modify Adrenal Cortex Morphology and Physiology.

Sofia S Pereira, Liliana Carvalho, Madalena M Costa, Armindo Melo, Isabel M P L V O Ferreira, Celso E Gomez-Sanchez, Mariana P Monteiro, Gavin Vinson, Duarte Pignatelli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Sofia S PereiraDepartment of Anatomy and Unit for Multidisciplinary Biomedical Research (UMIB) of Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0001-6947-4560
Liliana CarvalhoDepartment of Experimental Biology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.ORCID 0000-0001-9081-3184
Madalena M CostaDepartment of Anatomy and Unit for Multidisciplinary Biomedical Research (UMIB) of Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.
Armindo MeloDepartment of Environmental Health, National Institute of Health Dr. Ricardo Jorge, 4000-055 Porto, Portugal.ORCID 0000-0002-9153-0773
Isabel M P L V O FerreiraLaboratório Associado Para a Química Verde (LAQV/REQUIMTE), University of Porto, 4050-313 Porto, Portugal.
Celso E Gomez-SanchezEndocrinology Section, G.V. (Sonny) Montgomery VA Medical Center, Montgomery, AL 36109, USA.
Mariana P MonteiroDepartment of Anatomy and Unit for Multidisciplinary Biomedical Research (UMIB) of Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0002-0662-1831
Gavin VinsonThe School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK.
Duarte PignatelliDepartment of Experimental Biology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
Universidade do Porto · PTQueen Mary University of London · GBUniversity of Mississippi Medical Center · US

Funding

Fundação para a Ciência e a Tecnologia UIDB/00215/2020Fundação para a Ciência e a Tecnologia UIDP/00215/2020
6 · The paper itself

Abstract

Mineralocorticoid receptor antagonists (MRAs) are a class of anti-hypertensive drugs that act by blocking aldosterone action. The aim of this study was to evaluate whether the MRAs spironolactone and eplerenone influence adrenal cortical physiology and morphology. Spontaneous hypertensive rats (SHR,

Indexed as

adrenal cortexeplerenonemineralocorticoid receptor antagonistsspironolactonesteroids

Identifiers

PMID33924172
PMCPMC8074383
OpenAlexW3156554212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.