Evidence map›Paper›PMID 33924155›Full record

ArticleInternational journal of molecular sciences2021

Ferulic Acid Supplementation Increases Lifespan and Stress Resistance via Insulin/IGF-1 Signaling Pathway in

Hui Li, Xiaoxuan Yu, Fanwei Meng, Zhenyu Zhao, Shuwen Guan, Liping Wang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Insulin Affects Biological Behaviours ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Article
  6. Berberine Extends Lifespan inAntioxidants (Basel, Switzerland) · 2025
    Article
  7. Baicalein fromFrontiers in pharmacology · 2025
    Article
  8. Review
  9. Poplar Bud (Antioxidants (Basel, Switzerland) · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hui LiKey Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun 130012, China.
Xiaoxuan YuSchool of Life Sciences, Jilin University, Changchun 130012, China.
Fanwei MengSchool of Life Sciences, Jilin University, Changchun 130012, China.
Zhenyu ZhaoSchool of Life Sciences, Jilin University, Changchun 130012, China.
Shuwen GuanKey Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun 130012, China.
Liping WangKey Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun 130012, China.
Jilin University · CN

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Ferulic acid (FA) is a naturally-occurring well-known potent antioxidant and free radical scavenger. FA supplementation is an effective strategy to delay aging, but the underlying mechanism remains unknown. In the present study, we examined the effects of FA on lifespan extension and its mechanism of FA in

Indexed as

Dietary SupplementsLongevitySignal TransductionStress, PhysiologicalAnimalsAutophagyCaenorhabditis elegansCaenorhabditis elegans ProteinsCoumaric AcidsDNA-Binding ProteinsForkhead Transcription FactorsGene Expression ProfilingGenome-Wide Association StudyInsulinInsulin-Like Growth Factor IModels, BiologicalCaenorhabditis elegans ProteinsCoumaric Acidsdaf-16 protein, C elegansDNA-Binding Proteinsferulic acidForkhead Transcription Factorsheat shock factor-1, C elegansInsulinInsulin-Like Growth Factor IReactive Oxygen Speciesskn-1 protein, C elegansTranscription FactorsCaenorhabditis elegansferulic acidinsulin/IGF-1lifespanstress resistant

Identifiers

PMID33924155
PMCPMC8074393
OpenAlexW3155232291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.