ArticleNutrients2021
The Association of Healthy Aging with Multimorbidity: IKARIA Study.
Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Association of multimorbidity and its patterns with risk of mortality among the elderly in Shenzhen, China.BMC geriatrics · 2026Article
- Nutrition and longevity - diet in centenarians.Journal of translational medicine · 2026Review
- Prevalence and clinical risk factors of cardiovascular disease in patients with cancer: a cross-sectional study.BMC cardiovascular disorders · 2025Article
- Blue Zones, an Analysis of Existing Evidence through a Scoping Review.Aging and disease · 2025Article
- A simplified cardiac amyloidosis score predicts all-cause and cardiovascular disease mortality and morbidity in the general population: the Ikaria Study.Archives of medical science : AMS · 2025Article
- Multiomics of Aging and Aging-Related Diseases.International journal of molecular sciences · 2024Review
- Attitudes of Family Members and Caregivers Regarding Alzheimer's Disease Pre-Symptomatic Screening.Journal of Alzheimer's disease reports · 2024Article
- Comorbidity patterns in cardiovascular diseases: the role of life-stage and socioeconomic status.Frontiers in cardiovascular medicine · 2024Article
- Leveraging Digital Workflows to Transition the Orthotics and Prosthetics Profession Toward a Client-Centric and Values-Based Care Model.Canadian prosthetics & orthotics journal · 2023Article
- Sex differences in epigenetic age in Mediterranean high longevity regions.Frontiers in aging · 2022Article
- The Effect of Whole-Grain Diet on the Gut Microbiota of the Elderly Individuals.Frontiers in nutrition · 2022Article
- Spatiotemporal Analysis of the Prevalence and Pattern of Multimorbidity in Older Chinese Adults.Frontiers in medicine · 2021Article
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Authors and funding
9 authors.
Funding
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Abstract
The aim of this study was to evaluate several sociodemographic, lifestyle, and clinical characteristics of the IKARIA study participants and to find healthy aging trajectories of multimorbidity of Ikarian islanders. During 2009, 1410 people (aged 30+) from Ikaria Island, Greece, were voluntarily enrolled in the IKARIA study. Multimorbidity was defined as the combination of at least two of the following chronic diseases: hypertension; hypercholesterolemia; diabetes; obesity; cancer; CVD; osteoporosis; thyroid, renal, and chronic obstructive pulmonary disease. A healthy aging index (HAI) ranging from 0 to 100 was constructed using 4 attributes, i.e., depression symptomatology, cognitive function, mobility, and socializing. The prevalence of multimorbidity was 51% among men and 65.5% among women, while the average number of comorbidities was 1.7 ± 1.4 for men and 2.2 ± 1.4 for women. The most prevalent chronic diseases among men with multimorbidity were hypertension, hypercholesterolemia, and obesity while among women they were hypertension, hypercholesterolemia, and thyroid disease. Multimorbidity was correlated with HAI (Spearman's rho = -0.127,
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