Evidence map›Paper›PMID 33924053›Full record

ArticleInternational journal of molecular sciences2021

Cyclin-Dependent Kinase Inhibitor BMI-1026 Induces Apoptosis by Downregulating Mcl-1 (L) and c-FLIP (L) and Inactivating p-Akt in Human Renal Carcinoma Cells.

Dong Eun Kim, Jinho Lee, Jong Wook Park, Hyunsu Kang, Yu Ri Nam, Taeg Kyu Kwon, Ki-Suk Kim, Shin Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dong Eun KimDepartment of Immunology, School of Medicine, Keimyung University, 1095 Dalgubeol-daero, Dalseo-gu, Daegu 42601, Korea.
Jinho LeeDepartment of Chemistry, Keimyung University, 1095 Dalgubeol-daero, Dalseo-gu, Daegu 42601, Korea.
Jong Wook ParkDepartment of Immunology, School of Medicine, Keimyung University, 1095 Dalgubeol-daero, Dalseo-gu, Daegu 42601, Korea.
Hyunsu KangR&D Center for Advanced Pharmaceuticals & Evaluation, Korea Institute of Toxicology, Daejeon 34114, Korea.
Yu Ri NamR&D Center for Advanced Pharmaceuticals & Evaluation, Korea Institute of Toxicology, Daejeon 34114, Korea.
Taeg Kyu KwonDepartment of Immunology, School of Medicine, Keimyung University, 1095 Dalgubeol-daero, Dalseo-gu, Daegu 42601, Korea.ORCID 0000-0003-1204-2059
Ki-Suk KimR&D Center for Advanced Pharmaceuticals & Evaluation, Korea Institute of Toxicology, Daejeon 34114, Korea.
Shin KimDepartment of Immunology, School of Medicine, Keimyung University, 1095 Dalgubeol-daero, Dalseo-gu, Daegu 42601, Korea.ORCID 0000-0002-1099-5027
Keimyung University · KRKorea Institute of Toxicology · KR

Funding

national research foundation of korea 2014R1A5A2010008National Research Foundation of Korea NRF-2019R1I1A3A01063114
6 · The paper itself

Abstract

Previous studies have investigated the inhibitory effect of BMI-1026 on cyclin-dependent kinase 1 in vitro. However, the molecular mechanisms by which BMI-1026 treatment leads to cancer cell death remain unclear. This study was conducted to investigate the anticancer mechanisms of BMI-1026 on human renal carcinoma Caki cells. BMI-1026 induced apoptosis in association with the cleavage of poly(ADP-ribose) polymerase and pro-caspase-3 and the release of apoptosis-inducing factor and cytochrome

Indexed as

ApoptosisBlotting, WesternCarcinoma, Renal CellCASP8 and FADD-Like Apoptosis Regulating ProteinCell Line, TumorChromonesDown-RegulationFlow CytometryHCT116 CellsHumansMorpholinesPhenolsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPyrimidines2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneBMI 1026CASP8 and FADD-Like Apoptosis Regulating ProteinCFLAR protein, humanChromonesMorpholinesPhenolsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPyrimidinesapoptosisBMI-1026cellular FADD-like IL-1β-converting enzyme inhibitory proteinMcl-1p-Akt

Identifiers

PMID33924053
PMCPMC8073842
OpenAlexW3156980927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.