Evidence map›Paper›PMID 33924051›Full record

ArticleJournal of cardiovascular development and disease2021

A Heterozygous Mutation in Cardiac Troponin T Promotes Ca

Sarah M Kamel, Charlotte D Koopman, Fabian Kruse, Sven Willekers, Sonja Chocron, Jeroen Bakkers

Open access · goldAbstract read
In one paragraph

Article in Journal of cardiovascular development and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sarah M KamelHubrecht Institute-KNAW, University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands.ORCID 0000-0003-4424-9732
Charlotte D KoopmanHubrecht Institute-KNAW, University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands.
Fabian KruseHubrecht Institute-KNAW, University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands.
Sven WillekersHubrecht Institute-KNAW, University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands.
Sonja ChocronHubrecht Institute-KNAW, University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands.
Jeroen BakkersHubrecht Institute-KNAW, University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands.ORCID 0000-0002-9418-0422
University Medical Center Utrecht · NL

Funding

ZonMw 9003037607
6 · The paper itself

Abstract

Cardiomyopathies are a group of heterogeneous diseases that affect the muscles of the heart, leading to early morbidity and mortality in young and adults. Genetic forms of cardiomyopathy are caused predominantly by mutations in structural components of the cardiomyocyte sarcomeres, the contractile units of the heart, which includes cardiac Troponin T (TnT). Here, we generated mutations with CRISPR/Cas9 technology in the zebrafish

Indexed as

calcium dysregulationcardiac Troponin Tcardiomyopathycontractility defectsCRISPR/Cas9structural remodelingzebrafish

Identifiers

PMID33924051
PMCPMC8072640
OpenAlexW3156512081

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.