Evidence map›Paper›PMID 33923988›Full record

ArticleInternational journal of molecular sciences2021

Novel Quercetin Derivative of 3,7-Dioleylquercetin Shows Less Toxicity and Highly Potent Tyrosinase Inhibition Activity.

Moon-Hee Choi, Seung-Hwa Yang, Da-Song Kim, Nam Doo Kim, Hyun-Jae Shin, Kechun Liu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Flavonoids fromADMET & DMPK · 2024
    Review
  4. Heterocyclic Compounds as Synthetic Tyrosinase Inhibitors: Recent Advances.International journal of molecular sciences · 2023
    Review
  5. Ethyl Gallate Isolated fromAntioxidants (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Moon-Hee ChoiDepartment of Chemical Engineering, Graduate School of Chosun University, Gwangju 61452, Korea.
Seung-Hwa YangDepartment of Chemical Engineering, Graduate School of Chosun University, Gwangju 61452, Korea.ORCID 0000-0003-1160-0864
Da-Song KimDepartment of Chemical Engineering, Graduate School of Chosun University, Gwangju 61452, Korea.ORCID 0000-0001-9534-9990
Nam Doo KimVORONOI BIO Inc., Incheon 21984, Korea.
Hyun-Jae ShinDepartment of Chemical Engineering, Graduate School of Chosun University, Gwangju 61452, Korea.ORCID 0000-0002-2618-5643
Kechun LiuBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
Chosun University · KRQilu University of Technology · CN

Funding

National Research Foundation of Korea NRF-2020R1I1A1A01073631
6 · The paper itself

Abstract

Quercetin is a well-known plant flavonol and antioxidant; however, there has been some debate regarding the efficacy and safety of native quercetin as a skin-whitening agent via tyrosinase inhibition. Several researchers have synthesized quercetin derivatives as low-toxicity antioxidants and whitening agents. However, no suitable quercetin derivatives have been reported to date. In this study, a novel quercetin derivative was synthesized by the S

Indexed as

AnimalsAntineoplastic AgentsCell Line, TumorHumansKineticsMelaninsMolecular Docking SimulationQuercetinRNA, MessengerZebrafishAntineoplastic AgentsMelaninsQuercetinRNA, Messenger3,7-dioleylquercetinanti-melanogenesisenzyme kineticsquercetin derivativesskin whitening agenttyrosinase inhibitorzebrafish

Identifiers

PMID33923988
PMCPMC8072539
OpenAlexW3152992971

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.