Evidence map›Paper›PMID 33923826›Full record

ReviewMarine drugs2021

Symbioses of Cyanobacteria in Marine Environments: Ecological Insights and Biotechnological Perspectives.

Mirko Mutalipassi, Gennaro Riccio, Valerio Mazzella, Christian Galasso, Emanuele Somma, Antonia Chiarore, Donatella de Pascale, Valerio Zupo

Abstract readReview
In one paragraph

Review in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
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  7. Review
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  9. Vitamin BMicrobial genomics · 2026
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mirko MutalipassiDepartment of Marine Biotechnology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.ORCID 0000-0002-5521-5303
Gennaro RiccioDepartment of Marine Biotechnology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.
Valerio MazzellaDepartment of Integrated Marine Ecology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.ORCID 0000-0001-8708-2392
Christian GalassoDepartment of Marine Biotechnology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.ORCID 0000-0002-1262-959X
Emanuele SommaDepartment of Life Sciences, University of Trieste, Via Licio Giorgieri, 34127 Trieste, Italy.
Antonia ChiaroreDepartment of Biology, University of Naples Federico II, Via Cinthia, 80126 Naples, Italy.
Donatella de PascaleDepartment of Marine Biotechnology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.
Valerio ZupoDepartment of Marine Biotechnology, Ischia Marine Centre, Stazione Zoologica Anton Dohrn, Punta San Pietro, 80077 Naples, Italy.ORCID 0000-0001-9766-8784

Funding

Antitumor Drugs and Vaccines from the Sea (ADViSE) 804 project PG/2018/0494374
6 · The paper itself

Abstract

Cyanobacteria are a diversified phylum of nitrogen-fixing, photo-oxygenic bacteria able to colonize a wide array of environments. In addition to their fundamental role as diazotrophs, they produce a plethora of bioactive molecules, often as secondary metabolites, exhibiting various biological and ecological functions to be further investigated. Among all the identified species, cyanobacteria are capable to embrace symbiotic relationships in marine environments with organisms such as protozoans, macroalgae, seagrasses, and sponges, up to ascidians and other invertebrates. These symbioses have been demonstrated to dramatically change the cyanobacteria physiology, inducing the production of usually unexpressed bioactive molecules. Indeed, metabolic changes in cyanobacteria engaged in a symbiotic relationship are triggered by an exchange of infochemicals and activate silenced pathways. Drug discovery studies demonstrated that those molecules have interesting biotechnological perspectives. In this review, we explore the cyanobacterial symbioses in marine environments, considering them not only as diazotrophs but taking into consideration exchanges of infochemicals as well and emphasizing both the chemical ecology of relationship and the candidate biotechnological value for pharmaceutical and nutraceutical applications.

Indexed as

BioprospectingDietary SupplementsDrug DiscoveryEcosystemAnimalsAquatic OrganismsCyanobacteriaEvolution, MolecularHumansPharmaceutical PreparationsSecondary MetabolismSymbiosisPharmaceutical Preparationsanimal interactionsbioactive moleculescyanobiontsdiazotrophinfochemicalsprokaryotessecondary metabolites

Identifiers

PMID33923826
PMCPMC8074062

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.