ReviewNutrients2021
Alcohol Consumption in Rheumatoid Arthritis: A Path through the Immune System.
Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Alcohol Exposure and Disease Associations: A Mendelian Randomization and Meta-Analysis on Weekly Consumption and Problematic Drinking.Nutrients · 2024Pooled it
- Pooled it
- Review
- Impact of immunosuppressive therapy and clinical risk factors on the prevalence of low bone mineral density in rheumatic diseases.Frontiers in medicine · 2026Article
- A Brief Review of the Mediterranean Diet's Role in Mediating Inflammation and in Management of Rheumatoid Arthritis.The Permanente journal · 2025Review
- The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive Review.Nutrients · 2025Review
- Aging associated immunosenescence in rheumatoid arthritis identified by machine learning and single cell profiling.Scientific reports · 2025Article
- Association Between Chronic Obstructive Pulmonary Disease and Mortality in Participants with Arthritis: Data from the National Health and Nutrition Examination Survey 1999-2018.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025Article
- Analysis of data from the NHANES 1999-2018 and Mendelian randomization studies reveals the relationship between alcohol use and rheumatoid arthritis.Nutrition journal · 2024Article
- Dietary habit and risk of rheumatoid arthritis: a mendelian randomization study identifying protective and risk factors.European journal of nutrition · 2024Article
- Factors affecting the duration of initial medical care seeking among older rural patients diagnosed with rheumatoid arthritis: a retrospective cohort study.BMC rheumatology · 2024Article
- Prevalence and sociodemographic correlates of antinuclear antibody testing by indirect immunofluorescence or solid-phase assays in a Spanish population: the Camargo Cohort.Immunologic research · 2024Article
- Exploring the Therapeutic Potential ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Cardiovascular health worsening in patients with autoimmune rheumatological diseases during the COVID-19 pandemic.Clinical rheumatology · 2023Review
- Article
- The Integral Role of Diets Including Natural Products to Manage Rheumatoid Arthritis: A Narrative Review.Current issues in molecular biology · 2023Review
- Rheumatoid sarcopenia: loss of skeletal muscle strength and mass in rheumatoid arthritis.Nature reviews. Rheumatology · 2023Review
- Predictive risk factors before the onset of familial rheumatoid arthritis: the Tatarstan cohort study.Frontiers in medicine · 2023Article
- Alcohol abuse may increase the risk of autoimmune connective tissue disease: a nationwide population-based cohort study.Frontiers in psychiatry · 2023Article
- Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms ofDrug design, development and therapy · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Benefits and harms of different components of human diet have been known for hundreds of years. Alcohol is one the highest consumed, abused, and addictive substances worldwide. Consequences of alcohol abuse are increased risks for diseases of the cardiovascular system, liver, and nervous system, as well as reduced immune system function. Paradoxically, alcohol has also been a consistent protective factor against the development of autoimmune diseases such as type 1 diabetes, multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis (RA). Here, we focused on summarizing current findings on the effects of alcohol, as well as of its metabolites, acetaldehyde and acetate, on the immune system and RA. Heavy or moderate alcohol consumption can affect intestinal barrier integrity, as well as the microbiome, possibly contributing to RA. Additionally, systemic increase in acetate negatively affects humoral immune response, diminishing T
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.