ArticleJournal of clinical medicine2021
Increased Creatine Kinase May Predict A Worse COVID-19 Outcome.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Prognostic factors for mortality, intensive care unit and hospital admission due to SARS-CoV-2: a systematic review and meta-analysis of cohort studies in Europe.European respiratory review : an official journal of the European Respiratory Society · 2022Pooled it
- Comparison of biomarkers and laboratory results in unaffected, moderate, and severe COVID-19 recovered patients.Future science OA · 2025Article
- Musculoskeletal Complications in COVID-19: Exploring the Role of Key Biomarkers.International journal of molecular sciences · 2025Review
- Creatine and post-viral fatigue syndrome: an update.Journal of the International Society of Sports Nutrition · 2025Review
- Development of a risk prediction model for secondary infection in severe/critical COVID-19 patients.BMC infectious diseases · 2025Article
- Value of cardiac enzyme spectrum for the risk assessment of mortality in critically ill children: a single-centre retrospective study.BMJ open · 2024Article
- Coronavirus disease 2019 and its impact on the cognition of older adults: Unraveling the role of inflammation.Comprehensive psychoneuroendocrinology · 2024Article
- Comparison of clinical characteristics and disease burden of febrile seizures in children with and without COVID-19.BMC pediatrics · 2024Article
- Integration of individualized and population-level molecular epidemiology data to model COVID-19 outcomes.Cell reports. Medicine · 2024Article
- Physical condition and perceived fatigue in post-covid patients: An observational descriptive study.Sao Paulo medical journal = Revista paulista de medicina · 2024Observational
- The Characteristics and Laboratory Findings of SARS-CoV-2 Infected Patients during the First Three COVID-19 Waves in Portugal-A Retrospective Single-Center Study.Medicina (Kaunas, Lithuania) · 2023Article
- Development of a proteomic signature associated with severe disease for patients with COVID-19 using data from 5 multicenter, randomized, controlled, and prospective studies.Scientific reports · 2023Article
- Effects of Changing Veterinary Handling Techniques on Canine Behaviour and Physiology Part 1: Physiological Measurements.Animals : an open access journal from MDPI · 2023Article
- Detection of COVID-19-related biomarkers by electrochemical biosensors and potential for diagnosis, prognosis, and prediction of the course of the disease in the context of personalized medicine.Analytical and bioanalytical chemistry · 2023Review
- COVID-19 and Biomarkers: The Contribution of the Journal.Journal of clinical medicine · 2023Article
- An untargeted metabolomic approach to investigate antiviral defence mechanisms in memory leukocytes secreting anti-SARS-CoV-2 IgG in vitro.Scientific reports · 2023Article
- Clinical features of febrile seizures in children with COVID-19: an observational study from a tertiary care hospital in China.Frontiers in pediatrics · 2023Article
- Interleukin6 prediction of mortality in critically ill COVID19 patients: A prospective observational cohort study.PloS one · 2023Observational
- The Effects of Exercise Training on Recovery of Biochemical and Hematological Outcomes in Patients Surviving COVID-19: A Randomized Controlled Assessor-Blinded Trial.Sports medicine - open · 2022Article
- Skeletal Muscle Manifestations and Creatine Kinase in COVID-19.The Neurohospitalist · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early reports from Asia suggested that increased serum levels of the muscular enzyme creatine-(phospho)-kinase (CK/CPK) could be associated with a more severe prognosis in COVID-19. The aim of this single-center retrospective cohort study of 331 consecutive COVID-19 patients who were hospitalized during Italy's "first wave" was to verify this relationship, and to evaluate the role of possible confounding factors (age, body mass index, gender, and comorbidities). We subdivided our cohort in two groups, based on "severe" (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.