Evidence map›Paper›PMID 33923714›Full record

ArticleNutrients2021

Growth and Body Composition in PKU Children-A Three-Year Prospective Study Comparing the Effects of L-Amino Acid to Glycomacropeptide Protein Substitutes.

Anne Daly, Wolfgang Högler, Nicola Crabtree, Nick Shaw, Sharon Evans, Alex Pinto, Richard Jackson, Boyd J Strauss, Gisela Wilcox, Júlio C Rocha and 2 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Anne DalyBirmingham Women's and Children's Hospital, NHS Foundation Trust, Birmingham B4 6NH, UK.ORCID 0000-0003-2579-8699
Wolfgang HöglerDepartment of Paediatrics and Adolescent Medicine, Johannes Kepler University, Kepler University Hospital, Krankenhausstraße 26-30, 4020 Linz, Austria.
Nicola CrabtreeBirmingham Women's and Children's Hospital, NHS Foundation Trust, Birmingham B4 6NH, UK.ORCID 0000-0003-4328-6304
Nick ShawBirmingham Women's and Children's Hospital, NHS Foundation Trust, Birmingham B4 6NH, UK.
Sharon EvansBirmingham Women's and Children's Hospital, NHS Foundation Trust, Birmingham B4 6NH, UK.ORCID 0000-0002-7654-3621
Alex PintoBirmingham Women's and Children's Hospital, NHS Foundation Trust, Birmingham B4 6NH, UK.
Richard JacksonLiverpool Clinical Trials Centre, University of Liverpool, Brownlow Hill, Liverpool L69 3GL, UK.
Boyd J StraussSchool of Medical Sciences, Faculty of Biology, Medicine and Health Sciences, University of Manchester, Manchester M13 9PL, UK.
Gisela WilcoxSchool of Medical Sciences, Faculty of Biology, Medicine and Health Sciences, University of Manchester, Manchester M13 9PL, UK.ORCID 0000-0002-8953-2403
Júlio C RochaNutrition and Metabolism, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal.
Catherine AshmoreBirmingham Women's and Children's Hospital, NHS Foundation Trust, Birmingham B4 6NH, UK.
Anita MacDonaldBirmingham Women's and Children's Hospital, NHS Foundation Trust, Birmingham B4 6NH, UK.
Birmingham Women’s and Children’s NHS Foundation Trust · GBCentre for Health Technology and Services Research · PTKepler Universitätsklinikum · ATSalford Royal NHS Foundation Trust · GBUniversity of Liverpool · GBUniversity of Manchester · GB

Funding

Vitaflo 001
6 · The paper itself

Abstract

Protein quality and quantity are important factors in determining lean body (muscle) mass (LBM). In phenylketonuria (PKU), protein substitutes provide most of the nitrogen, either as amino acids (AA) or glycomacropeptide with supplementary amino acids (CGMP-AA). Body composition and growth are important indicators of long-term health. In a 3-year prospective study comparing the impact of AA and CGMP-AA on body composition and growth in PKU, 48 children were recruited.

Indexed as

Absorptiometry, PhotonAdolescentAmino AcidsBody CompositionBody HeightCaseinsChildChild, PreschoolDietary ProteinsDietary SupplementsFemaleGrowthHumansLongitudinal StudiesMalePeptide FragmentsAmino AcidscaseinomacropeptideCaseinsDietary ProteinsPeptide FragmentsPhenylalaninebody compositionglycomacropeptidephenylketonuriaprotein substitute

Identifiers

PMID33923714
PMCPMC8073059
OpenAlexW3140815554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.