Evidence map›Paper›PMID 33923709›Full record

ReviewBiomedicines2021

Anatomy, Pathophysiology, Molecular Mechanisms, and Clinical Management of Erectile Dysfunction in Patients Affected by Coronary Artery Disease: A Review.

Giuseppe Sangiorgi, Alberto Cereda, Daniela Benedetto, Michela Bonanni, Gaetano Chiricolo, Linda Cota, Eugenio Martuscelli, Francesco Greco

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Plant-based diets and urological health.Nature reviews. Urology · 2025
    Review
  14. Sexual medicine · 2025
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Giuseppe SangiorgiDepartment of Biomedicine and Prevention, University of Tor Vergata, 00133 Rome, Italy.ORCID 0000-0001-5862-1967
Alberto CeredaCardiac Catheterization Laboratory, Department of Cardiology, San Gaudenzio Hospital, 28100 Novara, Italy.
Daniela BenedettoDepartment of Biomedicine and Prevention, University of Tor Vergata, 00133 Rome, Italy.
Michela BonanniDepartment of Biomedicine and Prevention, University of Tor Vergata, 00133 Rome, Italy.ORCID 0000-0001-8069-592X
Gaetano ChiricoloDepartment of Biomedicine and Prevention, University of Tor Vergata, 00133 Rome, Italy.
Linda CotaDepartment of Biomedicine and Prevention, University of Tor Vergata, 00133 Rome, Italy.
Eugenio MartuscelliDepartment of Biomedicine and Prevention, University of Tor Vergata, 00133 Rome, Italy.
Francesco GrecoUrologic Clinic, Centro Salute Uomo, 24125 Bergamo, Italy.
University of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erectile dysfunction (ED) has been defined as the inability to attain or maintain penile erection sufficient for successful sexual intercourse. ED carries a notable influence on life quality, with significant implications for family and social relationships. Because atherosclerosis of penile arteries represents one of the most frequent ED causes, patients presenting with it should always be investigated for potential coexistent coronary or peripheral disease. Up to 75% of ED patients have a stenosis of the iliac-pudendal-penile arteries, supplying the male genital organ's perfusion. Recently, pathophysiology and molecular basis of male erection have been elucidated, giving the ground to pharmacological and mechanical revascularization treatment of this condition. This review will focus on the normal anatomy and physiology of erection, the pathophysiology of ED, the relation between ED and cardiovascular diseases, and, lastly, on the molecular basis of erectile dysfunction.

Indexed as

erectile dysfunctionNitrix Oxideperipheral atherosclerotic diseasesmooth muscle cells

Identifiers

PMID33923709
PMCPMC8074129
OpenAlexW3153512912

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.