Evidence map›Paper›PMID 33923628›Full record

ArticleVaccines2021

Phase I Trial Evaluating the Safety and Immunogenicity of Candidate TB Vaccine MVA85A, Delivered by Aerosol to Healthy

Michael Riste, Julia L Marshall, Iman Satti, Stephanie A Harris, Morven Wilkie, Raquel Lopez Ramon, Danny Wright, Rachel E Wittenberg, Samantha Vermaak, Rebecca Powell Doherty and 10 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02532036 (A Phase I Trial to Compare the Safety and Immunogenicity of Candidate TB Vaccine MVA85A Administered by the Aerosol Inhaled Route and the Intramuscular Route in Healthy Adult Volunteers Who Are Latently Infected With Mycobacterium Tuberculosis), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02532036 phase1terminatednot on this map

A Phase I Trial to Compare the Safety and Immunogenicity of Candidate TB Vaccine MVA85A Administered by the Aerosol Inhaled Route and the Intramuscular Route in Healthy Adult Volunteers Who Are Latently Infected With Mycobacterium Tuberculosis

TypeinterventionalSponsorUniversity of OxfordRan2015 to 2018Enrolled2ConditionsTuberculosisArmsAerosol inhaled MVA85A, Intramuscular MVA85A, Intramuscular Saline placebo, Aerosol inhaled Saline placebo
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Drug resistance mechanisms inFrontiers in pharmacology · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. OvercomingActa pharmaceutica Sinica. B · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 1 country.

Michael RisteThe Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.ORCID 0000-0002-7841-2430
Julia L MarshallThe Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
Iman SattiThe Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
Stephanie A HarrisThe Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
Morven WilkieThe Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
Raquel Lopez RamonThe Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
Danny WrightThe Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.ORCID 0000-0002-8114-1838
Rachel E WittenbergThe Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
Samantha VermaakThe Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
Rebecca Powell DohertyThe Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
Alison LawrieThe Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
Christopher P ConlonNuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK.ORCID 0000-0002-3531-2464
Catherine CosgroveTB Chest Clinic, St George's University Hospitals NHS Foundation Trust, London SW15 5PN, UK.
Fergus GleesonDepartment of Oncology, University of Oxford, Oxford OX3 7DQ, UK.
Marc LipmanRoyal Free London NHS Foundation Trust, London NW3 2QG, UK.
Paul MossInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
Felicity PerrinRespiratory Medicine, King's College Hospital NHS Foundation Trust, London SE5 9PJ, UK.
Martin DedicoatDepartment of Infection and Tropical Medicine, Heartlands Hospital, Birmingham B9 5SS, UK.
Henry BettinsonOxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Trust, Oxford OX3 7LE, UK.
Helen McShaneThe Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
University of Oxford · GBHeartlands Hospital · GBKing's College Hospital NHS Foundation Trust · GBOxford University Hospitals NHS Trust · GBRoyal Free London NHS Foundation Trust · GBSt George’s University Hospitals NHS Foundation Trust · GBUniversity of Birmingham · GB

Funding

National Institute for Health Research (NIHR) Oxford Biomedical Research Centre IS-BRC-1215-20008TBVAC2020 643381TuBerculosis Vaccine Initiative (TBVI) /DFID (TBVI) /DFIDWellcome TrustWellcome Trust WI 206331/Z/17/Z
6 · The paper itself

Abstract

The immunogenicity of the candidate tuberculosis (TB) vaccine MVA85A may be enhanced by aerosol delivery. Intradermal administration was shown to be safe in adults with latent TB infection (LTBI), but data are lacking for aerosol-delivered candidate TB vaccines in this population. We carried out a Phase I trial to evaluate the safety and immunogenicity of MVA85A delivered by aerosol in UK adults with LTBI (NCT02532036). Two volunteers were recruited, and the vaccine was well-tolerated with no safety concerns. Aerosolised vaccination with MVA85A induced mycobacterium- and vector-specific IFN-γ in blood and mycobacterium-specific Th1 cytokines in bronchoalveolar lavage. We identified several important barriers that could hamper recruitment into clinical trials in this patient population. The trial did not show any safety concerns in the aerosol delivery of a candidate viral-vectored TB vaccine to two UK adults with

Indexed as

aerosol vaccinelatent TB infectionMVA85Amycobacteria

Identifiers

PMID33923628
PMCPMC8073411
OpenAlexW3153651250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.