ReviewInternational journal of molecular sciences2021
Antibody Libraries as Tools to Discover Functional Antibodies and Receptor Pleiotropism.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- A functional and robust cellular model for high-throughput screening of piezo1 modulators.Scientific reports · 2026Article
- Technologies for Monoclonal Antibody Discovery and Development.International journal of molecular sciences · 2025Review
- In vivo antibody library screening identifies PKM2-targeting M1 antibody with antitumor activity in melanoma.American journal of cancer research · 2025Article
- Epitope-guided selection of CXCR4-targeting antibodies using AlphaFold3 for GPCR modulation and cancer therapy.American journal of cancer research · 2025Article
- An Antagonist Antibody That Inhibits Cancer Cell Growth In Vitro through RACK1.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Effects of Chemical Fixatives on Kinetic Measurements of Biomolecular Interaction on Cell Membrane.The Journal of membrane biology · 2024Article
- Establishing an ANO1-Based Cell Model for High-Throughput Screening Targeting TRPV4 Regulators.Molecules (Basel, Switzerland) · 2024Article
- Peptide Antibodies: Current Status.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Probing the Internalization and Efficacy of Antibody-Drug Conjugate via Site-Specific Fc-Glycan Labelling of a Homogeneous Antibody Targeting SSEA-4 Bearing Tumors.Israel journal of chemistry · 2023Article
- Establishment of a CaCC-based Cell Model and Method for High-throughput Screening of M3 Receptor Drugs.Cell biochemistry and biophysics · 2023Article
- Protocols for Screening Peptides Binding to CCN Family Proteins and Their Extended Utility.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Joined at the hip: The role of light chain complementarity determining region 2 in antibody self-association.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Recent Advances in Antibody Therapeutics.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Most antibodies currently in use have been selected based on their binding affinity. However, nowadays, antibodies that can not only bind but can also alter the function of cell surface signaling components are increasingly sought after as therapeutic drugs. Therefore, the identification of such functional antibodies from a large antibody library is the subject of intensive research. New methods applied to combinatorial antibody libraries now allow the isolation of functional antibodies in the cellular environment. These selected agonist antibodies have provided new insights into important issues of signal transduction. Notably, when certain antibodies bind to a given receptor, the cell fate induced by them may be the same or different from that induced by natural agonists. In addition, combined with phenotypic screening, this platform allows us to discover unexpected experimental results and explore various phenomena in cell biology, such as those associated with stem cells and cancer cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.