Evidence map›Paper›PMID 33923369›Full record

ReviewMarine drugs2021

Cyanobacteria-From the Oceans to the Potential Biotechnological and Biomedical Applications.

Shaden A M Khalifa, Eslam S Shedid, Essa M Saied, Amir Reza Jassbi, Fatemeh H Jamebozorgi, Mostafa E Rateb, Ming Du, Mohamed M Abdel-Daim, Guo-Yin Kai, Montaser A M Al-Hammady and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 120 citations in OpenAlex.

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  16. Biocompatibility ofInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 6 countries.

Shaden A M KhalifaDepartment of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden.
Eslam S ShedidDepartment of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt.
Essa M SaiedChemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt.ORCID 0000-0002-7342-6200
Amir Reza JassbiMedicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz 71348-53734, Iran.ORCID 0000-0003-3918-361X
Fatemeh H JamebozorgiMedicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz 71348-53734, Iran.
Mostafa E RatebSchool of Computing, Engineering & Physical Sciences, University of the West of Scotland, High Street, Paisley PA1 2BE, UK.ORCID 0000-0003-4043-2687
Ming DuSchool of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China.ORCID 0000-0001-5872-8529
Mohamed M Abdel-DaimPharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.ORCID 0000-0002-4341-2713
Guo-Yin KaiLaboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 311402, China.
Montaser A M Al-HammadyNational Institute of Oceanography & Fisheries, NIOF, Cairo 11516, Egypt.
Jianbo XiaoInstitute of Food Safety and Nutrition, Jinan University, Guangzhou 510632, China.
Zhiming GuoSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.ORCID 0000-0001-6416-7457
Hesham R El-SeediDepartment of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt.
Jiangsu University · CNShiraz University of Medical Sciences · IRSuez Canal University · EGDalian Polytechnic University · CNJinan University · CNMenoufia University · EGNational Institute of Oceanography and Fisheries · EGStockholm University · SEUniversity of the West of Scotland · GBZhejiang Chinese Medical University · CN

Funding

Stockholm University Swedish Research links grant VR 2016-05885
6 · The paper itself

Abstract

Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.

Indexed as

COVID-19 Drug TreatmentSARS-CoV-2Antiviral AgentsAquatic OrganismsCOVID-19CyanobacteriaHumansAntiviral Agentsantioxidantantiviralbiotechnological applicationsclinical trialsCOVID-19cyanobacteriadietary supplementstotal synthesis

Identifiers

PMID33923369
PMCPMC8146687
OpenAlexW3158735209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.