Evidence map›Paper›PMID 33923338›Full record

ArticleViruses2021

From Multiplex Serology to Serolomics-A Novel Approach to the Antibody Response against the SARS-CoV-2 Proteome.

Julia Butt, Rajagopal Murugan, Theresa Hippchen, Sylvia Olberg, Monique van Straaten, Hedda Wardemann, Erec Stebbins, Hans-Georg Kräusslich, Ralf Bartenschlager, Hermann Brenner and 5 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Julia ButtInfections and Cancer Epidemiology, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), 69120 Heidelberg, Germany.
Rajagopal MuruganB Cell Immunology, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0002-0336-7268
Theresa HippchenDepartment of Internal Medicine IV, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Sylvia OlbergDepartment of Infectious Diseases, Virology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Monique van StraatenDivision of Structural Biology of Infection and Immunity, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), 69120 Heidelberg, Germany.
Hedda WardemannB Cell Immunology, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), 69120 Heidelberg, Germany.
Erec StebbinsDivision of Structural Biology of Infection and Immunity, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), 69120 Heidelberg, Germany.
Hans-Georg KräusslichDepartment of Infectious Diseases, Virology, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0002-8756-329X
Ralf BartenschlagerGerman Center for Infection Research (DZIF), Heidelberg Partner Site, 69120 Heidelberg, Germany.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0002-6129-1572
Vibor LaketaDepartment of Infectious Diseases, Virology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Ben SchöttkerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0002-1217-4521
Barbara MüllerDepartment of Infectious Diseases, Virology, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0001-5726-5585
Uta MerleDepartment of Internal Medicine IV, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0003-1386-3350
Tim WaterboerInfections and Cancer Epidemiology, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), 69120 Heidelberg, Germany.
German Cancer Research Center · DEHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emerging SARS-CoV-2 pandemic entails an urgent need for specific and sensitive high-throughput serological assays to assess SARS-CoV-2 epidemiology. We, therefore, aimed at developing a fluorescent-bead based SARS-CoV-2 multiplex serology assay for detection of antibody responses to the SARS-CoV-2 proteome. Proteins of the SARS-CoV-2 proteome and protein N of SARS-CoV-1 and common cold Coronaviruses (ccCoVs) were recombinantly expressed in

Indexed as

AdultAgedAged, 80 and overAntibodies, ViralAntibody FormationAntigens, ViralCohort StudiesCoronavirus Nucleocapsid ProteinsCOVID-19Enzyme-Linked Immunosorbent AssayEscherichia coliFemaleHEK293 CellsHumansImmunoglobulin AImmunoglobulin GAntibodies, ViralAntigens, ViralCoronavirus Nucleocapsid ProteinsImmunoglobulin AImmunoglobulin GImmunoglobulin Mnucleocapsid phosphoprotein, SARS-CoV-2PhosphoproteinsProteomemultiplex serologySARS-CoV-2

Identifiers

PMID33923338
PMCPMC8147094
OpenAlexW3158761870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.