Evidence map›Paper›PMID 33923269›Full record

ArticleMicroorganisms2021

Antivirulence Properties of a Low-Molecular-Weight Quaternized Chitosan Derivative against

Giuseppantonio Maisetta, Anna Maria Piras, Vincenzo Motta, Simona Braccini, Diletta Mazzantini, Federica Chiellini, Ylenia Zambito, Semih Esin, Giovanna Batoni

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Multifaceted effects ofVirulence · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Giuseppantonio MaisettaDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
Anna Maria PirasDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-4082-6400
Vincenzo MottaDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-1443-1309
Simona BracciniDepartment of Chemistry and Industrial Chemistry, University of Pisa, UdR INSTM PISA, 56124 Pisa, Italy.ORCID 0000-0001-8188-9726
Diletta MazzantiniDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
Federica ChielliniDepartment of Chemistry and Industrial Chemistry, University of Pisa, UdR INSTM PISA, 56124 Pisa, Italy.ORCID 0000-0003-4680-9975
Ylenia ZambitoDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0003-0064-233X
Semih EsinDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-4358-5294
Giovanna BatoniDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-4448-2385
University of Pisa · IT

Funding

Funded by University of Pisa. Funds "Rating di Ateneo" to Giovanna Batoni and Semih Esin xxxxxxxx
6 · The paper itself

Abstract

The co-occurrence of increasing rates of resistance to current antibiotics and the paucity of novel antibiotics pose major challenges for the treatment of bacterial infections. In this scenario, treatments targeting bacterial virulence have gained considerable interest as they are expected to exert a weaker selection for resistance than conventional antibiotics. In a previous study, we demonstrated that a low-molecular-weight quaternized chitosan derivative, named QAL, displays antibiofilm activity against the major pathogen

Indexed as

biofilmchitosanLasAmotilityproteasesPseudomonas aeruginosapyocyaninpyoverdinquaternized chitosanquorum sensingtobramycinvirulence factors

Identifiers

PMID33923269
PMCPMC8145479
OpenAlexW3158346509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.