Evidence map›Paper›PMID 33923265›Full record

ArticleJournal of personalized medicine2021

Clinical Remission Using Personalized Low-Dose Intravenous Infusions of

Dipnarine Maharaj, Gayathri Srinivasan, Sarah Makepeace, Christopher J Hickey, Jacqueline Gouvea

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dipnarine MaharajDepartment of Medicine, The Maharaj Institute of Immune Regenerative Medicine, Boynton Beach, FL 33437, USA.ORCID 0000-0001-9825-1905
Gayathri SrinivasanDepartment of Medicine, The Maharaj Institute of Immune Regenerative Medicine, Boynton Beach, FL 33437, USA.
Sarah MakepeaceDepartment of Medicine, The Maharaj Institute of Immune Regenerative Medicine, Boynton Beach, FL 33437, USA.
Christopher J HickeyPalm Beach Atlantic University, West Palm Beach, FL 33401, USA.
Jacqueline GouveaDepartment of Medicine, The Maharaj Institute of Immune Regenerative Medicine, Boynton Beach, FL 33437, USA.
Maharaj Institute of Immune Regenerative Medicine · USPalm Beach Atlantic University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interstitial Cystitis or Bladder Pain Syndrome (IC/BPS) is a heterogeneous condition characterized by elevated levels of inflammatory cytokines, IL-1β, IL-6, IL-8, IL-10, TNF-α, and is associated with debilitating symptoms of pelvic pain and frequent urination. A standard of care for IC/BPS has not been established, and most patients must undergo a series of different treatment options, with potential for severe adverse events. Here, we report a patient with a 26-year history of IC/BPS following treatment with multiple therapies, including low doses of etodolac, amitriptyline and gabapentin, which she was unable to tolerate because of adverse effects, including headaches, blurred vision and cognitive impairment. The patient achieved a complete clinical remission with minimal adverse events after 16 cycles of

Indexed as

anti-inflammatory therapybladder pain syndromeIL-1βinflammationinterstitial cystitisN-acetylcysteinepersonalized medicinepro-inflammatory cytokinesTNF-α

Identifiers

PMID33923265
PMCPMC8145543
OpenAlexW3159509895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.