Evidence map›Paper›PMID 33923179›Full record

ArticleJournal of personalized medicine2021

Hexosylceramides and Glycerophosphatidylcholine GPC(36:1) Increase in Multi-Organ Dysfunction Syndrome Patients with Pediatric Intensive Care Unit Admission over 8-Day Hospitalization.

Mara Leimanis-Laurens, Emily Wolfrum, Karen Ferguson, Jocelyn R Grunwell, Dominic Sanfilippo, Jeremy W Prokop, Todd A Lydic, Surender Rajasekaran

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Mara Leimanis-LaurensPediatric Critical Care Unit, Helen DeVos Children's Hospital, Grand Rapids, MI 49503, USA.ORCID 0000-0003-0595-4578
Emily WolfrumBioinformatics & Biostatistics Core, Van Andel Institute, Grand Rapids, MI 49503, USA.
Karen FergusonPediatric Critical Care Unit, Helen DeVos Children's Hospital, Grand Rapids, MI 49503, USA.ORCID 0000-0001-7152-2082
Jocelyn R GrunwellPediatric Critical Care Medicine, Emory University & Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.
Dominic SanfilippoPediatric Critical Care Unit, Helen DeVos Children's Hospital, Grand Rapids, MI 49503, USA.
Jeremy W ProkopDepartment of Pediatric and Human Development, College of Human Medicine, Michigan State University, Life Sciences Bldg. 1355 Bogue Street, East Lansing, MI 48824, USA.
Todd A LydicCollaborative Mass Spectrometry Core, Department of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Surender RajasekaranPediatric Critical Care Unit, Helen DeVos Children's Hospital, Grand Rapids, MI 49503, USA.
Helen DeVos Children's Hospital · USMichigan State University · USEmory University · USSpectrum Health · USVan Andel Institute · US

Funding

Helen DeVos Children's Hospital Foundation #R51100881018Spectrum Health Office of Research #R51100431217
6 · The paper itself

Abstract

Glycero- and sphingo-lipids are important in plasma membrane structure, caloric storage and signaling. An un-targeted lipidomics approach for a cohort of critically ill pediatric intensive care unit (PICU) patients undergoing multi-organ dysfunction syndrome (MODS) was compared to sedation controls. After IRB approval, patients meeting the criteria for MODS were screened, consented (

Indexed as

critical illnessglycerolipidsglycerophosphatidylcholinelipidomicsmulti-organ dysfunction syndromepediatricssphingolipidssphingomyelin

Identifiers

PMID33923179
PMCPMC8145972
OpenAlexW3157538229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.