ArticleMedicina (Kaunas, Lithuania)2021
Herpes Simplex Keratitis in Patients with SARS-CoV-2 Infection: A Series of Five Cases.
Article in Medicina (Kaunas, Lithuania), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Systematic review with meta-analysis of active herpesvirus infections in patients with COVID-19: Old players on the new field.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023Pooled it
- Herpetic Eye Disease During the COVID-19 Pandemic at an Urban Hospital System.Ocular immunology and inflammation · 2025Article
- Changes in the spectrum of ocular disease during the COVID-19 pandemic in late 2022 in the Hubei Province.Scientific reports · 2025Observational
- Herpes simplex keratitis: A brief clinical overview.World journal of virology · 2024Review
- Abducens Nerve Palsy in a Patient with COVID-19: A Case Report.Sisli Etfal Hastanesi tip bulteni · 2024Article
- SARS-CoV-2 Induced Herpes Virus Reactivations and Related Implications in Oncohematology: When Lymphocytopenia Sets in and Immunosurveillance Drops Out.Microorganisms · 2023Article
- Coronavirus disease 19 (COVID-19) and viral keratouveitis - unraveling the mystery.Indian journal of ophthalmology · 2023Article
- Analysis of clinical characteristics and factors influencing herpes simplex virus keratitis.Frontiers in medicine · 2023Article
- Recurrent and De Novo Toxoplasmosis Retinochoroiditis following Coronavirus Disease 2019 Infection or Vaccination.Vaccines · 2022Article
- COVID-19-associated opportunistic infections: a snapshot on the current reports.Clinical and experimental medicine · 2022Review
- How Does SARS-CoV-2 Affect Our Eyes-What Have We Learnt So Far about the Ophthalmic Manifestations of COVID-19?Journal of clinical medicine · 2022Review
- Incidence and Risk Factors of Bilateral Herpetic Keratitis: 2022 Update.Tropical medicine and infectious disease · 2022Review
- COVID-19 and the eye: alternative facts The 2022 Bowman Club, David L. Easty lecture.BMJ open ophthalmology · 2022Review
- Stromal and endothelial herpes simplex virus keratitis reactivation in the convalescent period of COVID-19 - A case report.Indian journal of ophthalmology · 2022Article
- Relapsed Disciform Stromal Herpetic Keratitis Following mRNA COVID-19 Vaccination: A Case Report.Korean journal of ophthalmology : KJO · 2022Article
- Herpes Simplex Virus Re-Activation in Patients with SARS-CoV-2 Pneumonia: A Prospective, Observational Study.Microorganisms · 2021Article
- Ocular manifestations of COVID-19.Therapeutic advances in ophthalmologyReview
- Manifestations of coronavirus infection disease-19 in anterior eye segment: An up-to-date review.Oman journal of ophthalmologyReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herpes simplex virus type 1 (HSV-1) is a leading cause of infectious blindness worldwide. Most of the initial infection cases manifest as acute epithelial keratitis. Reactivation of herpesviruses is common in critically ill patients, including patients with severe Coronavirus disease (COVID-19). However, the data on COVID-19-related ocular infections is sparse, despite recent observations that more than 30% of COVID-19-infected patients had ocular manifestations. We report five cases of HSV-1 keratitis in COVID-19 patients. In total, five COVID-19 patients underwent ophthalmic examination, showing similar symptoms, including photophobia, tearing, decreased vision, eye redness, and pain. After initial assessment, tests of visual acuity and corneal sensitivity, a fluorescein staining test, and complete anterior and posterior segment examinations were performed. A diagnosis of HSV-1 keratitis was confirmed in all cases. Therapy was initiated using a local and systemic antiviral approach together with local antibiotic and mydriatic therapy. The complete reduction of keratitis symptoms and a clear cornea was achieved in all patients within 2 weeks. SARS-CoV-2 infection may be a risk factor for developing HSV-1 keratitis, or it may act as a potential activator of this ocular disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.