Evidence map›Paper›PMID 33923097›Full record

ArticleToxins2021

Mycotoxin Occurrence and Risk Assessment in Gluten-Free Pasta through UHPLC-Q-Exactive Orbitrap MS.

Josefa Tolosa, Yelko Rodríguez-Carrasco, Giulia Graziani, Anna Gaspari, Emilia Ferrer, Jordi Mañes, Alberto Ritieni

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Josefa TolosaDepartment of Food Chemistry and Toxicology, University of Valencia, Av. Vicent A. Estellés, s/n, Burjassot, 46100 Valencia, Spain.ORCID 0000-0003-2260-5257
Yelko Rodríguez-CarrascoDepartment of Food Chemistry and Toxicology, University of Valencia, Av. Vicent A. Estellés, s/n, Burjassot, 46100 Valencia, Spain.ORCID 0000-0002-6421-218X
Giulia GrazianiDepartment of Pharmacy, Università di Napoli Federico II, Via D. Montesano, 80131 Napoli, Italy.ORCID 0000-0003-3070-5389
Anna GaspariDepartment of Pharmacy, Università di Napoli Federico II, Via D. Montesano, 80131 Napoli, Italy.ORCID 0000-0001-7155-8624
Emilia FerrerDepartment of Food Chemistry and Toxicology, University of Valencia, Av. Vicent A. Estellés, s/n, Burjassot, 46100 Valencia, Spain.ORCID 0000-0002-5198-2521
Jordi MañesDepartment of Food Chemistry and Toxicology, University of Valencia, Av. Vicent A. Estellés, s/n, Burjassot, 46100 Valencia, Spain.ORCID 0000-0002-0289-4752
Alberto RitieniDepartment of Pharmacy, Università di Napoli Federico II, Via D. Montesano, 80131 Napoli, Italy.ORCID 0000-0003-0314-8839
Universitat de València · ESUniversity of Naples Federico II · IT

Funding

Generalitat Valenciana GV2020/020
6 · The paper itself

Abstract

Celiac disease (CD) is a genetic-based autoimmune disorder which is characterized by inflammation in the small intestinal mucosa due to the intolerance to gluten. Celiac people should consume products without gluten, which are elaborated mainly with maize or other cereals. Contamination of cereals with mycotoxins, such as fumonisins (FBs) and aflatoxins (AFs) is frequently reported worldwide. Therefore, food ingestion is the main source of mycotoxin exposure. A new analytical method was developed and validated for simultaneous analysis of 21 mycotoxins in gluten-free pasta, commonly consumed by celiac population as an alternative to conventional pasta. Ultrahigh-performance liquid chromatography coupled to quadrupole Orbitrap high-resolution mass spectrometry (UHPLC-Q-Exactive Orbitrap MS) was used for analyte separation and detection. The mycotoxins included in this work were those widely reported to occur in cereal samples, namely, ochratoxin-A (OTA), aflatoxins (AFB1, AFB2, AFG1 and AFG2), zearalenone (ZON), deoxynivalenol (DON), 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol (3-AcDON and 15-AcDON, respectively), nivalenol (NIV), neosolaniol (NEO), fusarenone-X, (FUS-X), T-2 toxin (T-2) and HT-2 toxin (HT-2), fumonisin B1 and B2 (FB1 and FB2, respectively), enniatins (ENN A, ENN A1, ENN B and ENN B1) and beauvericin (BEA). The validated method was successfully applied to 84 gluten-free pasta samples collected from several local markets of Campania region (Italy) during September to November 2020 to monitor the occurrence of mycotoxins and to assess the exposure to these food contaminants. A significant number of samples (95%) showed mycotoxin contamination, being

Indexed as

AdolescentAdultAgedChildChild, PreschoolChromatography, High Pressure LiquidDiet, Gluten-FreeEdible GrainFemaleFood MicrobiologyHumansMaleMass SpectrometryMiddle AgedMycotoxinsRisk AssessmentMycotoxinsexposuregluten-free pastaHRMS-Orbitrapliquid-chromatographymultiresidue methodmycotoxins

Identifiers

PMID33923097
PMCPMC8146712
OpenAlexW3159860967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.