Evidence map›Paper›PMID 33923029›Full record

ArticleCells2021

Transduction of Pig Small Airway Epithelial Cells and Distal Lung Progenitor Cells by AAV4.

Oliver G Chen, Steven E Mather, Christian M Brommel, Bradley A Hamilton, Annie Ehler, Raul Villacreses, Reda E Girgis, Mahmoud Abou Alaiwa, David A Stoltz, Joseph Zabner and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Identification of CD164 as an essential entry receptor for divergent adeno-associated viruses.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Oliver G ChenDepartment of Pediatrics & Human Development, Michigan State University, Grand Rapids, MI 49503, USA.ORCID 0000-0003-0267-0983
Steven E MatherDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
Christian M BrommelDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
Bradley A HamiltonDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
Annie EhlerDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
Raul VillacresesDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
Reda E GirgisPulmonary Medicine, Spectrum Health, Grand Rapids, MI 49503, USA.
Mahmoud Abou AlaiwaDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
David A StoltzDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
Joseph ZabnerDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
Xiaopeng LiDepartment of Pediatrics & Human Development, Michigan State University, Grand Rapids, MI 49503, USA.
University of Iowa · USMichigan State University · USSpectrum Health · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Respiratory virus infection in early cystic fibrosis lung diseaseP01HL091842 · NHLBI · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2008 to 2022
$34.2M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Pathology CoreP01HL152960 · NHLBI · UNIVERSITY OF IOWA · PI ENGELHARDT, JOHN F · 2020 to 2024
$11.6M
Cystic Fibrosis Foundation LI19XX0Cystic Fibrosis Foundation LIX15XX0Cystic Fibrosis Foundation LIX16G0Cystic Fibrosis Foundation STOLTZ19R0NHLBI NIH HHS P01 HL091842NHLBI NIH HHS P01 HL152960NIDDK NIH HHS P30 DK054759NIEHS NIH HHS P30 ES005605NIH HHS HL091842, HL51670
6 · The paper itself

Abstract

Cystic fibrosis (CF) is caused by genetic mutations of the CF transmembrane conductance regulator (CFTR), leading to disrupted transport of Cl

Indexed as

AnimalsCells, CulturedCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDependovirusGenetic VectorsHumansLungRespiratory MucosaStem CellsSwineCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorAAV4CFTRcystic fibrosis 1progenitor cellssmall airway epithelia

Identifiers

PMID33923029
PMCPMC8145967
OpenAlexW3159759875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.