Evidence map›Paper›PMID 33922988›Full record

ArticleCancers2021

Deep Learning Prediction of Metastasis in Locally Advanced Colon Cancer Using Binary Histologic Tumor Images.

Stefan Schiele, Tim Tobias Arndt, Benedikt Martin, Silvia Miller, Svenja Bauer, Bettina Monika Banner, Eva-Maria Brendel, Gerhard Schenkirsch, Matthias Anthuber, Ralf Huss and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Stefan SchieleInstitute of Mathematics, Augsburg University, 86159 Augsburg, Germany.
Tim Tobias ArndtInstitute of Mathematics, Augsburg University, 86159 Augsburg, Germany.ORCID 0000-0002-0700-6590
Benedikt MartinGeneral Pathology and Molecular Diagnostics, Medical Faculty, 86156 Augsburg, Germany.
Silvia MillerGeneral Pathology and Molecular Diagnostics, Medical Faculty, 86156 Augsburg, Germany.
Svenja BauerGeneral Pathology and Molecular Diagnostics, Medical Faculty, 86156 Augsburg, Germany.
Bettina Monika BannerGeneral Pathology and Molecular Diagnostics, Medical Faculty, 86156 Augsburg, Germany.
Eva-Maria BrendelGeneral Pathology and Molecular Diagnostics, Medical Faculty, 86156 Augsburg, Germany.
Gerhard SchenkirschTumor Data Management, University Hospital of Augsburg, 86156 Augsburg, Germany.
Matthias AnthuberGeneral, Visceral, and Transplantation Surgery, University Hospital of Augsburg, 86156 Augsburg, Germany.
Ralf HussGeneral Pathology and Molecular Diagnostics, Medical Faculty, 86156 Augsburg, Germany.
Bruno MärklGeneral Pathology and Molecular Diagnostics, Medical Faculty, 86156 Augsburg, Germany.
Gernot MüllerInstitute of Mathematics, Augsburg University, 86159 Augsburg, Germany.ORCID 0000-0002-4426-6252
University Hospital Augsburg · DEUniversity of Augsburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we developed the Binary ImaGe Colon Metastasis classifier (BIg-CoMet), a semi-guided approach for the stratification of colon cancer patients into two risk groups for the occurrence of distant metastasis, using an InceptionResNetV2-based deep learning model trained on binary images. We enrolled 291 colon cancer patients with pT3 and pT4 adenocarcinomas and converted one cytokeratin-stained representative tumor section per case into a binary image. Image augmentation and dropout layers were incorporated to avoid overfitting. In a validation collective (

Indexed as

colon cancerdeep learningpatternprognostic biomarkertumor architecturetumor stroma ratio

Identifiers

PMID33922988
PMCPMC8123276
OpenAlexW3158563192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.