Evidence map›Paper›PMID 33922935›Full record

ArticleBiomolecules2021

Electrospun Janus Beads-On-A-String Structures for Different Types of Controlled Release Profiles of Double Drugs.

Ding Li, Menglong Wang, Wen-Liang Song, Deng-Guang Yu, Sim Wan Annie Bligh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 87 citations in OpenAlex.

  1. Article
  2. Review
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  4. Electrospun nanofibers and their application as sensors for healthcare.Frontiers in bioengineering and biotechnology · 2025
    Review
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  8. Review
  9. Review
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  11. Review
  12. Article
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  14. Review
  15. Article
  16. Electrospun Nanofiber Membranes for Air Filtration: A Review.Nanomaterials (Basel, Switzerland) · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ding LiSchool of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Menglong WangSchool of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Wen-Liang SongSchool of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Deng-Guang YuSchool of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.ORCID 0000-0001-7825-4498
Sim Wan Annie BlighSchool of Health Sciences, Caritas Institute of Higher Education, Hong Kong 999077, China.
University of Shanghai for Science and Technology · CNSaint Francis University · HK

Funding

Joint project of USST-CIHE No. 20181116Natural Science Foundation of Shanghai No.20ZR1439000
6 · The paper itself

Abstract

A side-by-side electrospinning process characterized by a home-made eccentric spinneret was established to produce the Janus beads-on-a-string products. In this study, ketoprofen (KET) and methylene blue (MB) were used as model drugs, which loaded in Janus beads-on-a-string products, in which polyvinylpyrrolidone K90 (PVP K90) and ethyl cellulose (EC) were exploited as the polymer matrices. From SEM images, distinct nanofibers and microparticles in the Janus beads-on-a-string structures could be observed clearly. X-ray diffraction demonstrated that all crystalline drugs loaded in Janus beads-on-a-string products were transferred into the amorphous state. ATR-FTIR revealed that the components of prepared Janus nanostructures were compatibility. In vitro dissolution tests showed that Janus beads-on-a-string products could provide typical double drugs controlled-release profiles, which provided a faster immediate release of MB and a slower sustained release of KET than the electrospun Janus nanofibers. Drug releases from the Janus beads-on-a-string products were controlled through a combination of erosion mechanism (linear MB-PVP sides) and a typical Fickian diffusion mechanism (bead KET-EC sides). This work developed a brand-new approach for the preparation of the Janus beads-on-a-string nanostructures using side-by-side electrospinning, and also provided a fresh idea for double drugs controlled release and the potential combined therapy.

Indexed as

CelluloseDelayed-Action PreparationsDrug CarriersDrug Delivery SystemsDrug LiberationKetoprofenMethylene BlueMultifunctional NanoparticlesNanofibersPolymersX-Ray DiffractionCelluloseDelayed-Action PreparationsDrug Carriersethyl celluloseKetoprofenMethylene BluePolymersbeads-on-a-stringimmediate releaseJanus structureside-by-side electrospinningsustained release

Identifiers

PMID33922935
PMCPMC8146616
OpenAlexW3159887805

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.