Evidence map›Paper›PMID 33922925›Full record

ArticleMolecules (Basel, Switzerland)2021

Secretion of Mutant DNA and mRNA by the Exosomes of Breast Cancer Cells.

Olga E Andreeva, Yuri Y Shchegolev, Alexander M Scherbakov, Ekaterina I Mikhaevich, Danila V Sorokin, Margarita V Gudkova, Irina V Bure, Ekaterina B Kuznetsova, Dmitry S Mikhaylenko, Marina V Nemtsova and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Olga E AndreevaDepartment of Experimental Tumor Biology, Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia, 115522 Moscow, Russia.ORCID 0000-0002-6015-6619
Yuri Y ShchegolevDepartment of Experimental Tumor Biology, Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia, 115522 Moscow, Russia.ORCID 0000-0002-1490-6781
Alexander M ScherbakovDepartment of Experimental Tumor Biology, Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia, 115522 Moscow, Russia.ORCID 0000-0002-2974-9555
Ekaterina I MikhaevichDepartment of Experimental Tumor Biology, Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia, 115522 Moscow, Russia.
Danila V SorokinDepartment of Experimental Tumor Biology, Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia, 115522 Moscow, Russia.
Margarita V GudkovaDepartment of Experimental Tumor Biology, Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia, 115522 Moscow, Russia.
Irina V BureLaboratory of Medical Genetics, Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
Ekaterina B KuznetsovaLaboratory of Medical Genetics, Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
Dmitry S MikhaylenkoLaboratory of Medical Genetics, Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
Marina V NemtsovaLaboratory of Medical Genetics, Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
Dmitry V BagrovDepartment of Bioengineering, Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.ORCID 0000-0002-6355-7282
Mikhail A Krasil'nikovDepartment of Experimental Tumor Biology, Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia, 115522 Moscow, Russia.
Ministry of Health of the Russian Federation · RUSechenov University · RULomonosov Moscow State University · RU

Funding

Russian Foundation for Basic Research project 18-29-09016, experiments with exosomesRussian Science Foundation project 19-15-00245, experiments with fluorescent-labelled compounds
6 · The paper itself

Abstract

Exosomes are the small vesicles that are secreted by different types of normal and tumour cells and can incorporate and transfer their cargo to the recipient cells. The main goal of the present work was to study the tumour exosomes' ability to accumulate the parent mutant DNA or RNA transcripts with their following transfer to the surrounding cells. The experiments were performed on the MCF7 breast cancer cells that are characterized by the unique coding mutation in the

Indexed as

AllelesBreast NeoplasmsClass I Phosphatidylinositol 3-KinasesDNA, NeoplasmExosomesFemaleHumansMCF-7 CellsMutationRNA, MessengerClass I Phosphatidylinositol 3-KinasesDNA, NeoplasmPIK3CA protein, humanRNA, Messengerbreast cancer cellscancerDNA transferringexosomessignalling

Identifiers

PMID33922925
PMCPMC8123307
OpenAlexW3157778022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.