Evidence map›Paper›PMID 33922891›Full record

ArticleInternational journal of molecular sciences2021

AS-Quant: Detection and Visualization of Alternative Splicing Events with RNA-seq Data.

Naima Ahmed Fahmi, Heba Nassereddeen, Jaewoong Chang, Meeyeon Park, Hsinsung Yeh, Jiao Sun, Deliang Fan, Jeongsik Yong, Wei Zhang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Naima Ahmed FahmiDepartment of Computer Science, University of Central Florida, Orlando, FL 32816, USA.
Heba NassereddeenGenomics and Bioinformatics Cluster, University of Central Florida, Orlando, FL 32816, USA.
Jaewoong ChangDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA.
Meeyeon ParkDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA.
Hsinsung YehDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA.
Jiao SunDepartment of Computer Science, University of Central Florida, Orlando, FL 32816, USA.
Deliang FanSchool of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, AZ 85287, USA.
Jeongsik YongDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA.ORCID 0000-0002-2758-0450
Wei ZhangDepartment of Computer Science, University of Central Florida, Orlando, FL 32816, USA.ORCID 0000-0003-3605-9373
University of Central Florida · USUniversity of Minnesota · USArizona State University · US

Funding

The Role of Truncated mRNAs in CancerR01GM113952 · NIGMS · UNIVERSITY OF MINNESOTA · PI YONG, JEONGSIK · 2015 to 2023
$3.0M
National Science Foundation IIS 1755761 and FET 1908495NIGMS NIH HHS R01 GM113952NIH HHS 1R01GM113952-01A1
6 · The paper itself

Abstract

(1) Background: A simplistic understanding of the central dogma falls short in correlating the number of genes in the genome to the number of proteins in the proteome. Post-transcriptional alternative splicing contributes to the complexity of the proteome and is critical in understanding gene expression. mRNA-sequencing (RNA-seq) has been widely used to study the transcriptome and provides opportunity to detect alternative splicing events among different biological conditions. Despite the popularity of studying transcriptome variants with RNA-seq, few efficient and user-friendly bioinformatics tools have been developed for the genome-wide detection and visualization of alternative splicing events. (2) Results: We propose AS-Quant, (

Indexed as

Alternative SplicingSoftwareAnimalsComputational BiologyData VisualizationExonsFibroblastsMiceMolecular Sequence AnnotationSequence Analysis, RNAalternative splicingRNA-seqRT-PCRtranscriptomevisualization

Identifiers

PMID33922891
PMCPMC8123109
OpenAlexW3157326977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.