Evidence map›Paper›PMID 33922875›Full record

ArticleVaccines2021

Balanced Cellular and Humoral Immune Responses Targeting Multiple Antigens in Adults Receiving a Quadrivalent Inactivated Influenza Vaccine.

Esther Dawen Yu, Alba Grifoni, Aaron Sutherland, Hannah Voic, Eric Wang, April Frazier, Natalia Jimenez-Truque, Sandra Yoder, Sabrina Welsh, Stacey Wooden and 4 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 18 citations in OpenAlex.

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  15. Cell reports methods · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Esther Dawen YuCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-3970-3753
Alba GrifoniCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Aaron SutherlandCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0003-3772-5024
Hannah VoicCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Eric WangCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-2378-9505
April FrazierCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-4722-7304
Natalia Jimenez-TruqueVanderbilt Vaccine Research Program, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Sandra YoderVanderbilt Vaccine Research Program, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Sabrina WelshHuman Vaccines Project, New York, NY 10119, USA.
Stacey WoodenMerck & Co., Inc., Kenilworth, NJ 07033, USA.
Wayne KoffHuman Vaccines Project, New York, NY 10119, USA.
Buddy CreechVanderbilt Vaccine Research Program, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Alessandro SetteCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Ricardo da Silva AntunesCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0001-9785-5272
La Jolla Institute for Immunology · USVanderbilt University Medical Center · USHuman Immunome Project · USMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitisU19AI142742 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Alessandro Sette · 2019 to 2026
$32.8M
National Institute of Allergy and Infectious Diseases U19AI142742
6 · The paper itself

Abstract

The role of T cell immunity has been acknowledged in recent vaccine development and evaluation. We tested the humoral and cellular immune responses to Flucelvax

Indexed as

cytokine polarizationinfluenza virusesprotein immunodominanceT cellsvaccine

Identifiers

PMID33922875
PMCPMC8146362
OpenAlexW3142690901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.