Evidence map›Paper›PMID 33922831›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

The Repurposing of Acetylsalicylic Acid as a Photosensitiser to Inactivate the Growth of Cryptococcal Cells.

Adepemi O Ogundeji, Nozethu Mjokane, Olufemi S Folorunso, Carolina H Pohl, Martin M Nyaga, Olihile M Sebolai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Aspirin Combined with Antifungal Drugs SuppressesJournal of microbiology and biotechnology · 2025
    Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Adepemi O OgundejiDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein 9301, South Africa.ORCID 0000-0002-7886-0524
Nozethu MjokaneDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein 9301, South Africa.
Olufemi S FolorunsoDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein 9301, South Africa.ORCID 0000-0002-0485-2273
Carolina H PohlDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein 9301, South Africa.
Martin M NyagaNext Generation Sequencing Unit and Division of Virology, University of the Free State, Bloemfontein 9301, South Africa.ORCID 0000-0002-5017-5584
Olihile M SebolaiDepartment of Microbiology and Biochemistry, University of the Free State, Bloemfontein 9301, South Africa.ORCID 0000-0002-0182-1084
University of the Free State · ZA

Funding

National Research Foundation of South Africa UID 114321
6 · The paper itself

Abstract

Photodynamic treatment (PDT) is often successful when used against aerobic microbes, given their natural susceptibility to oxidative damage. To this end, the current study aimed to explore the photodynamic action of acetylsalicylic acid (ASA; aspirin, which is commonly used to treat non-infectious ailments), when administered to respiring cryptococcal cells. The treatment of cryptococcal cells, i.e., exposure to 0.5 or 1 mM of ASA in the presence of ultraviolet light (UVL) for 10 min, resulted in a significant (

Indexed as

acetylsalicylic acid (ASA, aspirin)CAP64capsuleCryptococcusmembrane potential (ΔΨM)photodynamic treatmentphotosensitiserultrastructure

Identifiers

PMID33922831
PMCPMC8146328
OpenAlexW3157377264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.