Evidence map›Paper›PMID 33922825›Full record

ArticleToxins2021

Anticoagulant Activity of

Taline D Kazandjian, Arif Arrahman, Kristina B M Still, Govert W Somsen, Freek J Vonk, Nicholas R Casewell, Mark C Wilkinson, Jeroen Kool

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Snake Venom PLAToxins · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Unraveling snake venom phospholipase APharmacological reports : PR · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Toxicon: X · 2022
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Taline D KazandjianCentre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.ORCID 0000-0002-5383-0505
Arif ArrahmanDepartment of Chemistry and Pharmaceutical Sciences, Division of Bioanalytical Chemistry, Faculty of Sciences, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081HV Amsterdam, The Netherlands.
Kristina B M StillDepartment of Chemistry and Pharmaceutical Sciences, Division of Bioanalytical Chemistry, Faculty of Sciences, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081HV Amsterdam, The Netherlands.
Govert W SomsenDepartment of Chemistry and Pharmaceutical Sciences, Division of Bioanalytical Chemistry, Faculty of Sciences, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081HV Amsterdam, The Netherlands.ORCID 0000-0003-4200-2015
Freek J VonkNaturalis Biodiversity Center, Darwinweg 2, 2333CR Leiden, The Netherlands.
Nicholas R CasewellCentre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.ORCID 0000-0002-8035-4719
Mark C WilkinsonCentre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
Jeroen KoolDepartment of Chemistry and Pharmaceutical Sciences, Division of Bioanalytical Chemistry, Faculty of Sciences, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081HV Amsterdam, The Netherlands.ORCID 0000-0002-0011-5612
Liverpool School of Tropical Medicine · GBVrije Universiteit Amsterdam · NLNaturalis Biodiversity Center · NLUniversity of Indonesia · ID

Funding

Lembaga Pengelola Dana Pendidikan S-5622/LPDP.4/2020Medical Research Council MR/S00016X/1UK Medical Research Council grant MR/S00016X/1Wellcome Trust 200517/Z/16/ZWellcome Trust and Royal Society Sir Henry Dale Fellowship 200517/Z/16/Z
6 · The paper itself

Abstract

Bites from elapid snakes typically result in neurotoxic symptoms in snakebite victims. Neurotoxins are, therefore, often the focus of research relating to understanding the pathogenesis of elapid bites. However, recent evidence suggests that some elapid snake venoms contain anticoagulant toxins which may help neurotoxic components spread more rapidly. This study examines the effects of venom from the West African black-necked spitting cobra (

Indexed as

AcetatesAnimalsAnticoagulantsBlood CoagulationChromatography, High Pressure LiquidElapid VenomsGas Chromatography-Mass SpectrometryHydroxamic AcidsIndolesKeto AcidsNajaPhospholipases A2ProteomicsAcetatesAnticoagulantsElapid VenomsHydroxamic AcidsIndolesKeto AcidsmarimastatPhospholipases A2varespladibcoagulopathymarimastatmass spectrometryNaja nigricollisnanofractionationsnakebitevarespladib

Identifiers

PMID33922825
PMCPMC8145175
OpenAlexW3158661292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.