Evidence map›Paper›PMID 33922802›Full record

Trial reportNutrients2021

High-Protein, Low-Glycaemic Meal Replacement Decreases Fasting Insulin and Inflammation Markers-A 12-Month Subanalysis of the ACOORH Trial.

Kerstin Kempf, Martin Röhling, Winfried Banzer, Klaus Michael Braumann, Martin Halle, David McCarthy, Hans Georg Predel, Isabelle Schenkenberger, Susanne Tan, Hermann Toplak and 3 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
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  7. Article
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  9. Review
  10. Effects of Brown Rice, Meal Replacements, and Anti-Obesity Drugs on Mitochondria in Obese Rats.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 3 countries.

Kerstin KempfWest-German Center of Diabetes and Health, Düsseldorf Catholic Hospital Group, 40591 Düsseldorf, Germany.ORCID 0000-0003-4285-3127
Martin RöhlingWest-German Center of Diabetes and Health, Düsseldorf Catholic Hospital Group, 40591 Düsseldorf, Germany.ORCID 0000-0002-2258-0582
Winfried BanzerDepartment of Sports Medicine, Institute for Sports and Sport Science, University of Frankfurt, 60487 Frankfurt, Germany.
Klaus Michael BraumannDepartment of Sports and Movement Medicine, Faculty of Psychology and Human Movement Sciences, University of Hamburg, 20148 Hamburg, Germany.
Martin HalleDepartment of Prevention, Rehabilitation and Sports Medicine, Klinikum rechts der Isar, Technical University of Munich (TUM), 80992 Munich, Germany.
David McCarthyPublic Health Nutrition Research Group, London Metropolitan University, London N7 8DB, UK.ORCID 0000-0002-8353-8441
Hans Georg PredelInstitute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, 50933 Cologne, Germany.
Isabelle SchenkenbergerKARDIOS, Cardiologists in Berlin, 10787 Berlin, Germany.
Susanne TanDepartment of Endocrinology, Diabetes and Metabolism and Division of Laboratory Research, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany.
Hermann ToplakDepartment of Medicine, Division of Endocrinology, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0002-7513-5167
Aloys BergFaculty of Medicine, University of Freiburg, 79117 Freiburg, Germany.
Stephan MartinWest-German Center of Diabetes and Health, Düsseldorf Catholic Hospital Group, 40591 Düsseldorf, Germany.
On Behalf Of Acoorh Study Group
Deutsches Diabetes-Zentrum e.V. · DEGerman Sport University Cologne · DEGoethe University Frankfurt · DELondon Metropolitan University · GBMedical University of Graz · ATTUM Klinikum · DEUniversität Hamburg · DEUniversity of Duisburg-Essen · DEUniversity of Freiburg · DE

Funding

Almased-Wellness-GmbH 98158
6 · The paper itself

Abstract

Lifestyle interventions, including meal replacement, are effective in the prevention and treatment of type-2-diabetes and obesity. Since insulin is the key weight regulator, we hypothesised that the addition of meal replacement to a lifestyle intervention reduces insulin levels more effectively than lifestyle intervention alone. In the international multicentre randomised controlled ACOORH (Almased Concept against Overweight and Obesity and Related Health Risk) trial, overweight or obese persons who meet the criteria for metabolic syndrome (

Indexed as

Glycemic IndexMealsAdultAgedBiomarkersBody WeightChronic DiseaseDietary ProteinsFastingFemaleHumansInflammationInsulinIntention to Treat AnalysisMaleMiddle AgedBiomarkersDietary ProteinsInsulinfasting insulinlifestyle interventionlow-carbohydratelow-glycaemic meal replacementmulticentre studyobesityoverweightprotein-richRCTweight reduction

Identifiers

PMID33922802
PMCPMC8145939
OpenAlexW3159539846

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.